1. Home
  2. Analysis
  3. Protelos
  4. Fosamax plus d

Protelos vs. Fosamax plus d: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Protelos and Fosamax plus d. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 45,539 people who take Protelos and Fosamax plus d, and is updated regularly.

What is Protelos?

Protelos has active ingredients of strontium ranelate. It is often used in osteoporosis. eHealthMe is studying from 302 Protelos users. Check the latest studies of Protelos.

What is Fosamax plus d?

Fosamax plus d has active ingredients of alendronate sodium; cholecalciferol. It is often used in osteoporosis. eHealthMe is studying from 1,845 Fosamax plus d users. Check the latest studies of Fosamax plus d.

On Jul, 03, 2026

45,539 people who take Protelos and Fosamax plus d are studied.

Protelos vs Fosamax plus d drug comparison reports.

Drugs being compared in this study:

  • Protelos (strontium ranelate)
  • Fosamax Plus D (alendronate sodium; cholecalciferol)

Most common side effects of the drugs, overall:

Click here to view

Most common side effects of the drugs, in long term (1+ years) use:

Click here to view

Drug effectiveness:

Protelos:

  • not at all: 4.76 %
  • somewhat: 19.05 %
  • moderate: 47.62 %
  • high: 28.57 %
  • very high: 0 %

Fosamax Plus D:

  • not at all: 2.5 %
  • somewhat: 27.5 %
  • moderate: 32.5 %
  • high: 37.5 %
  • very high: 0 %

Want to compare Protelos with Fosamax plus d?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Protelos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Fosamax plus d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on strontium ranelate and alendronate sodium; cholecalciferol (the active ingredients of Protelos and Fosamax plus d, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.