Tylox vs. Advil: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Tylox and Advil. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 494,745 people who take Tylox and Advil, and is updated regularly.
What is Tylox?
Tylox has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 369 Tylox users. Check the latest studies of Tylox.
What is Advil?
Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.
On Feb, 01, 2026
494,745 people who take Tylox and Advil are studied.
Drugs being compared in this study:
- Advil (ibuprofen)
- Tylox (acetaminophen; oxycodone hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Tylox:
- not at all: 2.0 %
- somewhat: 19.72 %
- moderate: 40.52 %
- high: 29.4 %
- very high: 8.36 %
Advil:
- not at all: 2.94 %
- somewhat: 24.37 %
- moderate: 38.49 %
- high: 26.3 %
- very high: 7.9 %
Want to compare Tylox with Advil?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
- Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
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Common Tylox side effects:
- Drug dependence: 113 reports
Browse all side effects of Tylox:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Advil side effects:
- Drug ineffective: 8,798 reports
- Headache (pain in head): 3,908 reports
- Pain in extremity: 1,923 reports
- Fever: 1,849 reports
- Abdominal pain upper: 1,712 reports
- Fall: 1,499 reports
- Abdominal discomfort: 1,492 reports
- Weight decreased: 1,430 reports
- Nasopharyngitis (inflammation of the nasopharynx): 1,257 reports
- Hypersensitivity: 1,212 reports
- Constipation: 1,204 reports
- Drug hypersensitivity: 1,158 reports
- Hypoaesthesia (reduced sense of touch or sensation): 1,114 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 1,074 reports
- Gait disturbance: 1,060 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1,013 reports
- Condition: 972 reports
- Muscle spasms (muscle contraction): 897 reports
- Anaemia (lack of blood): 856 reports
- Migraine (headache): 814 reports
- Injury: 810 reports
- Peripheral swelling: 795 reports
- Hair loss: 786 reports
- Overdose: 779 reports
- Oropharyngeal pain: 743 reports
- Oedema peripheral (superficial swelling): 719 reports
- Swallowing difficulty: 717 reports
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 692 reports
- Vision blurred: 674 reports
- Throat irritation: 672 reports
- Injection site pain: 655 reports
- Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 653 reports
- Heart rate increased: 649 reports
- Hyperhidrosis (abnormally increased sweating): 643 reports
- Abdominal distension: 637 reports
- Dehydration (dryness resulting from the removal of water): 634 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 621 reports
- Heart attack: 615 reports
- Emotional distress: 608 reports
- Influenza like illness: 604 reports
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 591 reports
- Infection: 588 reports
- Swelling face: 564 reports
- Balance disorder: 523 reports
- Therapeutic response unexpected: 511 reports
- Infusion related reaction: 494 reports
- Burning sensation: 486 reports
- White blood cell count decreased: 473 reports
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 452 reports
- Gastrointestinal disorder (functional problems of gastrointestinal tract): 449 reports
- Loss of consciousness: 433 reports
- Dry mouth: 423 reports
- Neuropathy peripheral (surface nerve damage): 418 reports
- Haemoglobin decreased: 407 reports
- Injection site erythema (redness at injection site): 403 reports
- Inflammation: 402 reports
- General physical health deterioration (weak health status): 400 reports
- Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 395 reports
- Bone pain: 383 reports
- Mobility decreased (ability to move is reduced): 382 reports
- Rectal haemorrhage (bleeding from anus): 380 reports
- Haemorrhage (bleeding): 374 reports
- Visual impairment: 373 reports
- Drug effect decreased: 372 reports
- Nervousness: 371 reports
- Arthropathy: 366 reports
- Flatulence (flatus expelled through the anus): 361 reports
- Suicidal ideation: 347 reports
- Eye swelling: 344 reports
- Alanine aminotransferase increased: 332 reports
- Discomfort: 320 reports
- Stomatitis (inflammation of mucous membrane of mouth): 313 reports
- Renal disorder (kidney disease): 311 reports
- Productive cough: 310 reports
- Gastritis (inflammation of stomach): 309 reports
- Bone disorder: 308 reports
- Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 307 reports
- Cardiac disorder: 301 reports
- Irritable bowel syndrome: 300 reports
- Lip swelling: 299 reports
- Hepatic enzyme increased: 282 reports
- Depressed mood: 281 reports
- Disturbance in attention: 277 reports
- Aspartate aminotransferase increased: 275 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 274 reports
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 268 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 267 reports
- Cataract (clouding of the lens inside the eye): 264 reports
- Skin exfoliation (removal of the oldest dead skin cells): 256 reports
- Skin discoloration: 255 reports
- White blood cell count increased: 251 reports
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 248 reports
- Injection site bruising: 245 reports
- Haematemesis (vomiting of blood): 244 reports
- Gallbladder disorder: 242 reports
- Speech disorder: 234 reports
- Colitis (inflammation of colon): 233 reports
- Rash pruritic (redness with itching): 225 reports
- Heart rate decreased: 221 reports
- Blood creatinine increased: 220 reports
- Lung disorder (lung disease): 219 reports
- Renal impairment (severely reduced kidney function): 218 reports
- Disease recurrence: 215 reports
- Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 213 reports
- Pancreatitis (inflammation of pancreas): 211 reports
- Pain in jaw: 209 reports
- Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 208 reports
- Throat tightness: 207 reports
- Blood pressure systolic increased: 206 reports
- Osteonecrosis of jaw (death of bone of jaw): 205 reports
- Acute upper airway obstruction (blockage occurs in the upper airway): 204 reports
- Confusion: 202 reports
- Rash macular (small, flat red spots): 201 reports
- Dyspnea exertional: 200 reports
- Fear: 197 reports
- Ill-defined disorder: 192 reports
- Staphylococcal infection (an infection with staphylococcus bacteria): 190 reports
- Joint stiffness: 189 reports
- Injection site swelling: 184 reports
- Crying: 183 reports
- Feeling cold: 181 reports
- Impaired healing: 180 reports
- Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 175 reports
- Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 174 reports
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 173 reports
- Toothaches (tooth pain): 172 reports
- Osteomyelitis (infection of bone): 171 reports
- C-reactive protein increased: 170 reports
- Oral herpes (viral infection of mouth): 169 reports
- Dysstasia (difficulty in standing): 167 reports
- Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 166 reports
- Drug effect delayed: 165 reports
- Localised infection (infection at the single location): 164 reports
- Metastases to bone (cancer spreads to bone): 163 reports
- Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 162 reports
- Drug administration error: 159 reports
- Ankylosing spondylitis (type of arthritis affecting the spine): 158 reports
- Surgery: 157 reports
- Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 156 reports
- Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 155 reports
- Haemorrhoids (a swollen vein or group of veins in the region of the anus): 150 reports
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 146 reports
- Poor quality sleep: 144 reports
- Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 143 reports
- Musculoskeletal chest pain (pain in chest muscle or nerve or bones): 141 reports
- Blood alkaline phosphatase increased: 138 reports
- Synovitis (inflammation of the synovial membrane): 137 reports
- Eating disorder: 135 reports
- Foot fracture: 133 reports
- Urinary retention (the inability to completely or partially empty the bladder): 132 reports
- Impaired work ability: 131 reports
- Respiratory tract infection: 130 reports
- Vaginal bleeding: 128 reports
- Sedation: 126 reports
- Activities of daily living impaired: 125 reports
- Blood pressure diastolic increased: 124 reports
- Visual acuity reduced (reduced clearness of vision): 122 reports
- Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect): 120 reports
- Tricuspid valve incompetence (inefficient heart valve): 119 reports
- Hyperglycemia (high blood sugar): 118 reports
- Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 117 reports
- Neoplasm progression (growth of tumour): 115 reports
- Pharyngitis (inflammation of the pharynx, causing a sore throat): 114 reports
- Ascites (accumulation of fluid in the abdominal cavity): 113 reports
- Eyelid oedema (eyelids are swollen and contain excessive fluid): 111 reports
- Weight loss: 110 reports
- Leukocytosis (increased white blood cells): 109 reports
- Thyroid diseases: 108 reports
- Eye pruritus (eye itching): 107 reports
- Tooth loss: 105 reports
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 103 reports
- Neoplasm malignant (cancer tumour): 101 reports
Browse all side effects of Advil:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on acetaminophen; oxycodone hydrochloride and ibuprofen (the active ingredients of Tylox and Advil, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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