Valproate sodium vs. Sertraline hydrochloride: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Valproate sodium and Sertraline hydrochloride. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 323,367 people who take Valproate sodium and Sertraline hydrochloride, and is updated regularly.
What is Valproate sodium?
Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.
What is Sertraline hydrochloride?
Sertraline hydrochloride has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 28,199 Sertraline hydrochloride users. Check the latest studies of Sertraline hydrochloride.
323,367 people who take Valproate sodium and Sertraline hydrochloride are studied.

Drugs being compared in this study:
- Valproate Sodium (valproate sodium)
- Sertraline Hydrochloride (sertraline hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Valproate Sodium:
- not at all: 3.88 %
- somewhat: 11.89 %
- moderate: 28.64 %
- high: 40.53 %
- very high: 15.05 %
Sertraline Hydrochloride:
- not at all: 3.5 %
- somewhat: 19.85 %
- moderate: 36.3 %
- high: 30.77 %
- very high: 9.59 %
Want to compare Valproate sodium with Sertraline hydrochloride?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
- Bansal S, Gupta SK, "Sodium Valproate induced priapism in an adult with bipolar affective disorder", Indian journal of pharmacology, 2013 Jan .
- Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
- Bansal S, Gupta SK, "Sodium Valproate induced priapism in an adult with bipolar affective disorder", Indian journal of pharmacology, 2013 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Valproate sodium (23,476 reports)
- Sertraline hydrochloride (25,999 reports)
Browse all side effects of Valproate sodium:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Sertraline hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on valproate sodium and sertraline hydrochloride (the active ingredients of Valproate sodium and Sertraline hydrochloride, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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