Lamictal vs. Wellbutrin xl: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Lamictal and Wellbutrin xl. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 343,654 people who take Lamictal and Wellbutrin xl, and is updated regularly.
What is Lamictal?
Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 82,627 Lamictal users. Check the latest studies of Lamictal.
What is Wellbutrin xl?
Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 22,999 Wellbutrin xl users. Check the latest studies of Wellbutrin xl.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
343,654 people who take Lamictal and Wellbutrin xl are studied.

Drugs being compared in this study:
- Lamictal (lamotrigine)
- Wellbutrin Xl (bupropion hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Lamictal:
- not at all: 3.17 %
- somewhat: 16.87 %
- moderate: 31.05 %
- high: 31.54 %
- very high: 17.37 %
Wellbutrin Xl:
- not at all: 3.22 %
- somewhat: 21.31 %
- moderate: 37.28 %
- high: 29.15 %
- very high: 9.04 %
Want to compare Lamictal with Wellbutrin xl?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
- Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .
- Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
- Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Lamictal (74,243 reports)
- Wellbutrin xl (18,205 reports)
Browse all side effects of Lamictal:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Wellbutrin xl:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on lamotrigine and bupropion hydrochloride (the active ingredients of Lamictal and Wellbutrin xl, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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