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Hyperaesthesia and drugs of ingredients of acetaminophen (a real world drug study)


Summary:

Hyperaesthesia is found among people who take drugs with ingredients of acetaminophen, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 505,490 people who have side effects when taking drugs with ingredients of acetaminophen from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Acephen, Acetaminophen, Infants' feverall, Injectapap, Neopap, Ofirmev, Panadol, Paracetamol, Tylenol.

On Dec, 13, 2025

505,490 people reported to have side effects when taking drugs with ingredients of acetaminophen.
Among them, 567 people (0.11%) have Hyperaesthesia

What is Hyperaesthesia?

Hyperaesthesia is found to be associated with 921 drugs and 908 conditions by eHealthMe. Check the latest studies of Hyperaesthesia.

Number of reports submitted per year:

Could drugs with ingredients of acetaminophen cause Hyperaesthesia?

Time on drugs with ingredients of acetaminophen when people have Hyperaesthesia *:

  • < 1 month: 79.49 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 5.13 %
  • 1 - 2 years: 12.82 %
  • 2 - 5 years: 2.56 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hyperaesthesia when taking drugs with ingredients of acetaminophen *:

  • female: 67.04 %
  • male: 32.96 %

Age of people who have Hyperaesthesia when taking drugs with ingredients of acetaminophen *:

  • 0-1: 1.3 %
  • 2-9: 0.87 %
  • 10-19: 2.6 %
  • 20-29: 4.55 %
  • 30-39: 13.2 %
  • 40-49: 12.55 %
  • 50-59: 18.4 %
  • 60+: 46.54 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 65 people, 11.46%
  2. Back Pain: 37 people, 6.53%
  3. Stress And Anxiety: 34 people, 6.00%
  4. Local Anaesthesia: 33 people, 5.82%
  5. Sedation: 33 people, 5.82%
  6. Depression: 30 people, 5.29%
  7. High Blood Pressure: 30 people, 5.29%
  8. Papillary Thyroid Cancer: 26 people, 4.59%
  9. Lung Cancer - Non-Small Cell (lung cancer): 22 people, 3.88%
  10. Prostate Cancer: 20 people, 3.53%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Synthroid: 69 people, 12.17%
  2. Oxycodone: 69 people, 12.17%
  3. Morphine: 63 people, 11.11%
  4. Cymbalta: 62 people, 10.93%
  5. Folic Acid: 51 people, 8.99%
  6. Lyrica: 50 people, 8.82%
  7. Morphine Sulfate: 48 people, 8.47%
  8. Actemra: 48 people, 8.47%
  9. Coumadin: 46 people, 8.11%
  10. Pantoprazole: 46 people, 8.11%

Other side effects people have besides Hyperaesthesia *:

You may use this to check any potential undetected side effects.

  1. Nausea (feeling of having an urge to vomit): 174 people, 30.69%
  2. Weakness: 171 people, 30.16%
  3. Fatigue (feeling of tiredness): 165 people, 29.10%
  4. Joint Pain: 138 people, 24.34%
  5. Back Pain: 127 people, 22.40%
  6. Dizziness: 122 people, 21.52%
  7. Pain In Extremity: 117 people, 20.63%
  8. Diarrhea: 112 people, 19.75%
  9. Nausea And Vomiting: 109 people, 19.22%
  10. Dyspnea (difficult or laboured breathing): 103 people, 18.17%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of acetaminophen, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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