Hepatic necrosis and drugs of ingredients of clonidine (a real world drug study)
Summary:
Hepatic necrosis is found among people who take drugs with ingredients of clonidine, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 67,042 people who have side effects when taking drugs with ingredients of clonidine from the FDA, and is updated regularly.
Drug(s) considered in the study (i.e. both brand name and generic drugs): Catapres-tts-1, Catapres-tts-2, Catapres-tts-3, Clonidine, Nexiclon xr.
67,042 people reported to have side effects when taking drugs with ingredients of clonidine.
Among them, 30 people (0.04%) have Hepatic necrosis
What is Hepatic necrosis?
Hepatic necrosis (large portions of liver die off due to severe liver disease) is found to be associated with 591 drugs and 743 conditions by eHealthMe. Check the latest studies of Hepatic necrosis.
Number of reports submitted per year:

Time on drugs with ingredients of clonidine when people have Hepatic necrosis *:
- < 1 month: 100 %
- 1 - 6 months: 0.0 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
Gender of people who have Hepatic necrosis when taking drugs with ingredients of clonidine *:
- female: 58.62 %
- male: 41.38 %
Age of people who have Hepatic necrosis when taking drugs with ingredients of clonidine *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 3.45 %
- 30-39: 3.45 %
- 40-49: 20.69 %
- 50-59: 27.59 %
- 60+: 44.83 %
Conditions people have *:
You may use this to check any potential undetected conditions.
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 26.67%
- Stress And Anxiety: 2 people, 6.67%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.67%
- Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 3.33%
- Hiv Infection: 1 person, 3.33%
Other drugs people take *:
You may use this to check any potential interacting drugs.
- Prednisone: 13 people, 43.33%
- Nystatin: 9 people, 30.00%
- Gabapentin: 9 people, 30.00%
- Nifedipine: 8 people, 26.67%
- Lorazepam: 7 people, 23.33%
- Cerebyx: 7 people, 23.33%
- Famotidine: 7 people, 23.33%
- Ibuprofen: 7 people, 23.33%
- Atenolol: 6 people, 20.00%
- Lasix: 6 people, 20.00%
Other side effects people have besides Hepatic necrosis *:
You may use this to check any potential undetected side effects.
- Acute Kidney Failure: 11 people, 36.67%
- Multi-Organ Failure (multisystem organ failure): 10 people, 33.33%
- Cardiac Arrest: 9 people, 30.00%
- Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 9 people, 30.00%
- Hepatic Failure (liver failure): 9 people, 30.00%
- Drowsiness: 8 people, 26.67%
- Drug Hypersensitivity: 8 people, 26.67%
- Hyperkalemia (damage to or disease of the kidney): 8 people, 26.67%
- Hypotension (abnormally low blood pressure): 8 people, 26.67%
- Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 8 people, 26.67%
* Approximation only. Some reports may have incomplete information.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
- Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Related studies
Drugs with ingredients of clonidine, their effectiveness, alternatives and more:
How the study uses the data?
The study uses data from the FDA. It is based on clonidine. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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