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Poikiloderma and drugs of ingredients of estradiol (a real world drug study)


Summary:

Poikiloderma is found among people who take drugs with ingredients of estradiol, especially for people who are female, 50-59 old . This phase IV clinical study is created by eHealthMe based on reports of 68,472 people who have side effects when taking drugs with ingredients of estradiol from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Alora, Climara, Divigel, Elestrin, Esclim, Estrace, Estraderm, Estradiol, Estring, Estrogel, Evamist, Fempatch, Gynodiol, Imvexxy, Innofem, Menostar, Minivelle, Vagifem, Vivelle, Vivelle-dot.

On Aug, 06, 2026

68,472 people reported to have side effects when taking drugs with ingredients of estradiol.
Among them, 25 people (0.04%) have Poikiloderma

What is Poikiloderma?

Poikiloderma (pigmentary and atrophic changes in the skin) is found to be associated with 35 drugs and 42 conditions by eHealthMe. Check the latest studies of Poikiloderma.

Number of reports submitted per year:

Could drugs with ingredients of estradiol cause Poikiloderma?

Gender of people who have Poikiloderma when taking drugs with ingredients of estradiol *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Poikiloderma when taking drugs with ingredients of estradiol *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 87.5 %
  • 60+: 12.5 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 25 people, 100.00%
  2. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 23 people, 92.00%
  3. Antinuclear Antibody Positive: 10 people, 40.00%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Zantac: 24 people, 96.00%
  2. Bactrim: 24 people, 96.00%
  3. Diovan: 24 people, 96.00%
  4. Elavil: 24 people, 96.00%
  5. Prolia: 23 people, 92.00%
  6. Methylprednisolone: 17 people, 68.00%
  7. Cyclophosphamide: 17 people, 68.00%
  8. Diphenhydramine Hydrochloride: 17 people, 68.00%
  9. Ezetimibe: 17 people, 68.00%
  10. Famotidine: 17 people, 68.00%

Other side effects people have besides Poikiloderma *:

You may use this to check any potential undetected side effects.

  1. Weight Increased: 24 people, 96.00%
  2. Joint Range Of Motion Decreased (disease of joint movement): 24 people, 96.00%
  3. Iron Binding Capacity Total Decreased: 24 people, 96.00%
  4. Urinary Tract Infection: 24 people, 96.00%
  5. Interstitial Lung Disease: 24 people, 96.00%
  6. Indigestion: 24 people, 96.00%
  7. Heart Rate Increased: 24 people, 96.00%
  8. Haemoglobin Decreased: 24 people, 96.00%
  9. Haematocrit Decreased: 24 people, 96.00%
  10. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 24 people, 96.00%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of estradiol, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on estradiol. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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