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Hypercoagulation and drugs of ingredients of levonorgestrel (a real world drug study)


Summary:

Hypercoagulation is found among people who take drugs with ingredients of levonorgestrel, especially for people who are female, 40-49 old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 225,610 people who have side effects when taking drugs with ingredients of levonorgestrel from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Athentia next, Fallback solo, Her style, Jadelle, Kyleena, Levonorgestrel, Liletta, Mirena, Norplant, Norplant ii, Norplant system in plastic container, Opcicon one-step, Plan b, Plan b one-step, Skyla.

On Jun, 20, 2026

225,610 people reported to have side effects when taking drugs with ingredients of levonorgestrel.
Among them, 20 people (0.01%) have Hypercoagulation

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 392 drugs and 537 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

Number of reports submitted per year:

Could drugs with ingredients of levonorgestrel cause Hypercoagulation?

Time on drugs with ingredients of levonorgestrel when people have Hypercoagulation *:

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hypercoagulation when taking drugs with ingredients of levonorgestrel *:

  • female: 94.12 %
  • male: 5.88 %

Age of people who have Hypercoagulation when taking drugs with ingredients of levonorgestrel *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 21.43 %
  • 30-39: 35.71 %
  • 40-49: 35.71 %
  • 50-59: 0.0 %
  • 60+: 7.14 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 10.00%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.00%
  3. Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 1 person, 5.00%
  4. Multiple Myeloma (cancer of the plasma cells): 1 person, 5.00%
  5. Migraine (headache): 1 person, 5.00%
  6. High Blood Pressure: 1 person, 5.00%
  7. Headache (pain in head): 1 person, 5.00%
  8. Chronic Thyroiditis (long lasting inflammation of thyroid gland): 1 person, 5.00%
  9. Cardiac Failure: 1 person, 5.00%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Amlodipine: 2 people, 10.00%
  2. Nuvaring: 2 people, 10.00%
  3. Zovirax: 1 person, 5.00%
  4. Lo/ovral: 1 person, 5.00%
  5. Amoxicillin And Clavulanate Potassium: 1 person, 5.00%
  6. Carvedilol: 1 person, 5.00%
  7. Coumadin: 1 person, 5.00%
  8. Elavil: 1 person, 5.00%
  9. Eprex: 1 person, 5.00%
  10. Glucotrol: 1 person, 5.00%

Other side effects people have besides Hypercoagulation *:

You may use this to check any potential undetected side effects.

  1. Headache (pain in head): 4 people, 20.00%
  2. Weight Increased: 3 people, 15.00%
  3. Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 15.00%
  4. Arrhythmias (irregular heartbeat): 3 people, 15.00%
  5. Migraine (headache): 3 people, 15.00%
  6. Nausea (feeling of having an urge to vomit): 3 people, 15.00%
  7. Oedema Peripheral (superficial swelling): 3 people, 15.00%
  8. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 3 people, 15.00%
  9. Vision Blurred: 3 people, 15.00%
  10. Speech Impairment (Adult) (inability to speak (adult)): 3 people, 15.00%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of levonorgestrel, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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