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Sinus node dysfunction and drugs of ingredients of niacin (a real world drug study)


Summary:

Sinus node dysfunction is found among people who take drugs with ingredients of niacin, especially for people who are male, 60+ old , have been taking the drugs for 10+ years. This phase IV clinical study is created by eHealthMe based on reports of 54,178 people who have side effects when taking drugs with ingredients of niacin from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Niacin, Niacor, Niaspan, Niaspan titration starter pack, Nicolar, Vitamin b3, Wampocap.

On Oct, 12, 2025

54,178 people reported to have side effects when taking drugs with ingredients of niacin.
Among them, 25 people (0.05%) have Sinus node dysfunction

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,249 drugs and 835 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

Number of reports submitted per year:

Could drugs with ingredients of niacin cause Sinus node dysfunction?

Time on drugs with ingredients of niacin when people have Sinus node dysfunction *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 100 %

Gender of people who have Sinus node dysfunction when taking drugs with ingredients of niacin *:

  • female: 20 %
  • male: 80 %

Age of people who have Sinus node dysfunction when taking drugs with ingredients of niacin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 22.73 %
  • 50-59: 0.0 %
  • 60+: 77.27 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Stress And Anxiety: 6 people, 24.00%
  2. Depression: 6 people, 24.00%
  3. Blood Testosterone Decreased: 3 people, 12.00%
  4. Prostatic Disorder: 3 people, 12.00%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.00%
  6. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.00%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.00%
  8. Arteriospasm Coronary (spasm of the large- or medium-sized coronary arteries): 2 people, 8.00%
  9. Prostatomegaly (enlargement of the prostate): 2 people, 8.00%
  10. Neuralgia (pain in one or more nerves): 1 person, 4.00%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Digoxin: 10 people, 40.00%
  2. Crestor: 9 people, 36.00%
  3. Coumadin: 9 people, 36.00%
  4. Aspirin: 8 people, 32.00%
  5. Lipitor: 8 people, 32.00%
  6. Zocor: 7 people, 28.00%
  7. Nexium: 7 people, 28.00%
  8. Nitroglycerin: 7 people, 28.00%
  9. Norvasc: 6 people, 24.00%
  10. Lasix: 6 people, 24.00%

Other side effects people have besides Sinus node dysfunction *:

You may use this to check any potential undetected side effects.

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 15 people, 60.00%
  2. Nausea And Vomiting: 6 people, 24.00%
  3. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 6 people, 24.00%
  4. High Blood Pressure: 6 people, 24.00%
  5. Weakness: 5 people, 20.00%
  6. Heart Attack: 5 people, 20.00%
  7. Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 20.00%
  8. Nausea (feeling of having an urge to vomit): 5 people, 20.00%
  9. Fatigue (feeling of tiredness): 5 people, 20.00%
  10. Cardiomyopathy (weakening of the heart muscle): 4 people, 16.00%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

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How the study uses the data?

The study uses data from the FDA. It is based on niacin. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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