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Latent tuberculosis and drugs of ingredients of tacrolimus (a real world drug study)


Summary:

Latent tuberculosis is found among people who take drugs with ingredients of tacrolimus, especially for people who are female, 60+ old , have been taking the drugs for 6 - 12 months. This phase IV clinical study is created by eHealthMe based on reports of 164,313 people who have side effects when taking drugs with ingredients of tacrolimus from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Astagraf xl, Envarsus xr, Prograf, Protopic, Tacrolimus.

On Aug, 10, 2026

164,313 people reported to have side effects when taking drugs with ingredients of tacrolimus.
Among them, 37 people (0.02%) have Latent tuberculosis

What is Latent tuberculosis?

Latent tuberculosis (hidden tuberculosis) is found to be associated with 160 drugs and 384 conditions by eHealthMe. Check the latest studies of Latent tuberculosis.

Number of reports submitted per year:

Could drugs with ingredients of tacrolimus cause Latent tuberculosis?

Time on drugs with ingredients of tacrolimus when people have Latent tuberculosis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Latent tuberculosis when taking drugs with ingredients of tacrolimus *:

  • female: 78.12 %
  • male: 21.88 %

Age of people who have Latent tuberculosis when taking drugs with ingredients of tacrolimus *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 3.45 %
  • 20-29: 6.9 %
  • 30-39: 17.24 %
  • 40-49: 3.45 %
  • 50-59: 6.9 %
  • 60+: 62.07 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Myositis (inflammation of the muscles): 19 people, 51.35%
  2. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 27.03%
  3. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 16.22%
  4. Diarrhea: 3 people, 8.11%
  5. Pain: 3 people, 8.11%
  6. Nausea (feeling of having an urge to vomit): 3 people, 8.11%
  7. Multiple Myeloma (cancer of the plasma cells): 3 people, 8.11%
  8. Irritability: 3 people, 8.11%
  9. Erection Problems: 3 people, 8.11%
  10. Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 2 people, 5.41%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Prolia: 19 people, 51.35%
  2. Septra: 19 people, 51.35%
  3. Synthroid: 19 people, 51.35%
  4. Cellcept: 18 people, 48.65%
  5. Vitamin D3: 18 people, 48.65%
  6. Apixaban: 9 people, 24.32%
  7. Stelara: 3 people, 8.11%
  8. Bortezomib: 3 people, 8.11%
  9. Cyclophosphamide: 3 people, 8.11%
  10. Deltasone: 3 people, 8.11%

Other side effects people have besides Latent tuberculosis *:

You may use this to check any potential undetected side effects.

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 19 people, 51.35%
  2. Swallowing Difficulty: 19 people, 51.35%
  3. Interstitial Lung Disease: 19 people, 51.35%
  4. Autoimmune Hepatitis: 19 people, 51.35%
  5. Nonspecific Reaction (unspecified reaction): 11 people, 29.73%
  6. Nosocomial Infection (infection from hospital): 6 people, 16.22%
  7. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 6 people, 16.22%
  8. Disease Recurrence: 6 people, 16.22%
  9. Congestive Cardiomyopathy (weakening of heart muscle): 6 people, 16.22%
  10. Inflammation: 6 people, 16.22%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of tacrolimus, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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