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Pancreatitis and drugs of ingredients of tolvaptan (a real world drug study)


Summary:

Pancreatitis is found among people who take drugs with ingredients of tolvaptan, especially for people who are female, 60+ old , have been taking the drugs for 1 - 6 months. This phase IV clinical study is created by eHealthMe based on reports of 13,739 people who have side effects when taking drugs with ingredients of tolvaptan from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Jynarque, Samsca, Tolvaptan.

On Aug, 05, 2026

13,739 people reported to have side effects when taking drugs with ingredients of tolvaptan.
Among them, 22 people (0.16%) have Pancreatitis

What is Pancreatitis?

Pancreatitis (inflammation of pancreas) is found to be associated with 1,763 drugs and 2,027 conditions by eHealthMe. Check the latest studies of Pancreatitis.

Number of reports submitted per year:

Could drugs with ingredients of tolvaptan cause Pancreatitis?

Time on drugs with ingredients of tolvaptan when people have Pancreatitis *:

  • < 1 month: 33.33 %
  • 1 - 6 months: 66.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Pancreatitis when taking drugs with ingredients of tolvaptan *:

  • female: 75 %
  • male: 25 %

Age of people who have Pancreatitis when taking drugs with ingredients of tolvaptan *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 35.71 %
  • 40-49: 7.14 %
  • 50-59: 7.14 %
  • 60+: 50.0 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. High Blood Pressure: 5 people, 22.73%
  2. Hyperkalemia (damage to or disease of the kidney): 2 people, 9.09%
  3. Inappropriate Antidiuretic Hormone Secretion: 2 people, 9.09%
  4. Allergies: 2 people, 9.09%
  5. Cataract (clouding of the lens inside the eye): 2 people, 9.09%
  6. Dehydration (dryness resulting from the removal of water): 2 people, 9.09%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.09%
  8. Headache (pain in head): 2 people, 9.09%
  9. Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 9.09%
  10. Abdominal Pain: 2 people, 9.09%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Amlodipine: 3 people, 13.64%
  2. Seasonique: 3 people, 13.64%
  3. Mavik: 3 people, 13.64%
  4. Adempas: 2 people, 9.09%
  5. Selexipag: 2 people, 9.09%
  6. Gabapentin: 2 people, 9.09%
  7. Pantoprazole: 2 people, 9.09%
  8. Belsomra: 2 people, 9.09%
  9. Zofran: 1 person, 4.55%
  10. Cellcept: 1 person, 4.55%

Other side effects people have besides Pancreatitis *:

You may use this to check any potential undetected side effects.

  1. Abdominal Pain: 4 people, 18.18%
  2. Anaemia (lack of blood): 3 people, 13.64%
  3. Renal Impairment (severely reduced kidney function): 3 people, 13.64%
  4. Liver Disorder (liver diseases): 3 people, 13.64%
  5. Malaise (a feeling of general discomfort or uneasiness): 3 people, 13.64%
  6. Dehydration (dryness resulting from the removal of water): 2 people, 9.09%
  7. Gout (uric acid crystals building up in the body): 2 people, 9.09%
  8. Concomitant Disease Progression (progress in accompanying disease): 2 people, 9.09%
  9. Cholangitis (infection of the bile duct): 2 people, 9.09%
  10. Hypotension (abnormally low blood pressure): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

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Drugs with ingredients of tolvaptan, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on tolvaptan. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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