Brain herniation and drugs of ingredients of zolpidem tartrate (a real world drug study)
Summary:
Brain herniation is found among people who take drugs with ingredients of zolpidem tartrate, especially for people who are male, 60+ old . This phase IV clinical study is created by eHealthMe based on reports of 174,921 people who have side effects when taking drugs with ingredients of zolpidem tartrate from the FDA, and is updated regularly.
Drug(s) considered in the study (i.e. both brand name and generic drugs): Ambien, Ambien cr, Edluar, Intermezzo, Stilnoct, Tovalt odt, Zolpidem, Zolpidem tartrate, Zolpidem tatrate, Zolpimist.
174,921 people reported to have side effects when taking drugs with ingredients of zolpidem tartrate.
Among them, 37 people (0.02%) have Brain herniation
What is Brain herniation?
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull) is found to be associated with 337 drugs and 975 conditions by eHealthMe. Check the latest studies of Brain herniation.
Number of reports submitted per year:

Gender of people who have Brain herniation when taking drugs with ingredients of zolpidem tartrate *:
- female: 50 %
- male: 50 %
Age of people who have Brain herniation when taking drugs with ingredients of zolpidem tartrate *:
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 6.9 %
- 20-29: 20.69 %
- 30-39: 3.45 %
- 40-49: 0.0 %
- 50-59: 3.45 %
- 60+: 65.52 %
Conditions people have *:
You may use this to check any potential undetected conditions.
- Heart Attack: 7 people, 18.92%
- Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 18.92%
- Stress And Anxiety: 6 people, 16.22%
- Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 8.11%
- Fungal Nail Infection: 2 people, 5.41%
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 5.41%
- Arrhythmias (irregular heartbeat): 2 people, 5.41%
- Nausea (feeling of having an urge to vomit): 2 people, 5.41%
- Blood Uric Acid Increased: 2 people, 5.41%
- Constipation: 2 people, 5.41%
Other drugs people take *:
You may use this to check any potential interacting drugs.
- Tylenol: 12 people, 32.43%
- Plavix: 10 people, 27.03%
- Nitroglycerin: 8 people, 21.62%
- Cymbalta: 8 people, 21.62%
- Lipitor: 8 people, 21.62%
- Protonix: 8 people, 21.62%
- Paxil: 8 people, 21.62%
- Integrilin: 7 people, 18.92%
- Fentanyl: 7 people, 18.92%
- Versed: 7 people, 18.92%
Other side effects people have besides Brain herniation *:
You may use this to check any potential undetected side effects.
- Subdural Haematoma (blood collects between the skull and the surface of the brain): 11 people, 29.73%
- Atelectasis (partial or complete collapse of the lung): 10 people, 27.03%
- Haemoglobin Decreased: 9 people, 24.32%
- Cerebral Haemorrhage (bleeding within the brain): 8 people, 21.62%
- Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 8 people, 21.62%
- Pneumonia: 8 people, 21.62%
- Pulmonary Oedema (fluid accumulation in the lungs): 8 people, 21.62%
- Nausea (feeling of having an urge to vomit): 7 people, 18.92%
- Urinary Tract Infection: 7 people, 18.92%
- Brain Death: 6 people, 16.22%
* Approximation only. Some reports may have incomplete information.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
- Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
- Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
- Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .
- Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
- Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
- Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
- Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .
Related studies
Drugs with ingredients of zolpidem tartrate, their effectiveness, alternatives and more:
How the study uses the data?
The study uses data from the FDA. It is based on zolpidem tartrate. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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