Pentasa and Methotrexate drug interactions for men aged 20-29 (a phase IV clinical study of FDA data)

Summary:

Drug interactions are found for men aged 20-29 who take Pentasa (mesalamine) and Methotrexate (methotrexate sodium) together. We list drug interactions by the duration when the drugs are taken. This phase IV study is created by eHealthMe based on reports of 62 people from the FDA, and is updated regularly.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 22, 2026

62 men aged 20-29 who take Pentasa, Methotrexate and have drug interactions are studied.


What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

Number of reports submitted per year:

Pentasa and Methotrexate drug interactions in men aged 20-29.

Most common drug interactions over time *:

< 1 month:

n/a

1 - 6 months:

n/a

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

  1. Agitation (state of anxiety or nervous excitement)
  2. Anxiety
  3. Personality change
  4. Restlessness (not able to rest)
  5. Skin disorder (skin disease)
  6. Stress
  7. Weight gain poor
  8. Abnormal loss of weight
  9. Cachexia (loss of weight)
  10. Muscle atrophy (a decrease in the mass of the muscle)

10+ years:

n/a

* Approximation only. Some reports may have incomplete information.

Do you take Pentasa and Methotrexate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



Related publications that referenced our studies:

Related studies:

How the study uses the data?

The study is based on (applicable) gender, age, mesalamine and methotrexate sodium (the active ingredients of Pentasa and Methotrexate, respectively), and Pentasa and Methotrexate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: