Methotrexate and Noises or buzzing in the ears for Men aged 50-59 (a phase IV clinical study of FDA data)

Summary:

Noises or buzzing in the ears is found for men aged 50-59 who take Methotrexate (methotrexate sodium). This study is created by eHealthMe based on reports of 24,989 men aged 50-59 from the FDA, and is updated regularly. The information that eHealthMe analyzes includes:

Time on Methotrexate when people have Noises or buzzing in the ears
Top conditions
Top co-used drugs
Top other side effects

On Mar, 22, 2026

24,989 men aged 50-59 reported to have side effects when taking Methotrexate.
Among them, 98 people (0.39%) have Noises or buzzing in the ears

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,310 Methotrexate users. Check the latest studies of Methotrexate.

What is Noises or buzzing in the ears?

Noises or buzzing in the ears is found to be associated with 2,404 drugs and 3,188 conditions by eHealthMe. Check the latest studies of Noises or buzzing in the ears.

Number of reports submitted per year:

Could Methotrexate cause Noises or buzzing in the ears in men aged 50-59?

Time on Methotrexate when people have Noises or buzzing in the ears *

Severity of Noises or buzzing in the ears

n/a

How people recovered from Noises or buzzing in the ears

n/a

Top conditions involved for these people *:

You may use this to check any potential undetected conditions.

Pain: 23 people, 23.47%
High Blood Pressure: 17 people, 17.35%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 17 people, 17.35%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 16 people, 16.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 14 people, 14.29%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 14 people, 14.29%
Gastritis (inflammation of stomach): 14 people, 14.29%
High Blood Cholesterol: 14 people, 14.29%
Ill-Defined Disorder: 14 people, 14.29%
Psoriasis (immune-mediated disease that affects the skin): 7 people, 7.14%

Top co-used drugs for these people *:

You may use this to check any potential interacting drugs.

Top other side effects for these people *:

You may use this to check any potential undetected side effects.

Headache (pain in head): 60 people, 61.22%
Dizziness: 39 people, 39.80%
Pain In Extremity: 29 people, 29.59%
Pain: 26 people, 26.53%
Stress And Anxiety: 25 people, 25.51%
Drug Ineffective: 24 people, 24.49%
Rashes (redness): 22 people, 22.45%
Fatigue (feeling of tiredness): 22 people, 22.45%
Angiopathy (generic term for a disease of the blood vessels): 21 people, 21.43%
Weight Decreased: 21 people, 21.43%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Noises or buzzing in the ears?

- Check whether Noises or buzzing in the ears is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related publications that referenced our studies:

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

Related studies:

Methotrexate and Noises or buzzing in the ears

How the study uses the data?

The study is based on (applicable) gender, age, methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.