Accolate and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accolate (zafirlukast) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include anaemia among females and rectal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Accolate and Flexeril. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Accolate?

Accolate has active ingredients of zafirlukast. It is often used in asthma. eHealthMe is studying from 4,220 Accolate users. Check the latest studies of Accolate.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

80 people who take Accolate and Flexeril together, and have interactions are studied.

Accolate and Flexeril drug interactions.

What are the common drug interactions of Accolate and Flexeril, by gender? *:

female:

Anaemia (lack of blood)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Hypoacusis (loss of hearing)
Insomnia (sleeplessness)
Pain
Pain in extremity
Pneumonia
Chest pain
Deafness
Diarrhoea

male:

Rectal haemorrhage (bleeding from anus)
Anxiety
Weight decreased
Abdominal pain upper
Fatigue (feeling of tiredness)
Fistula (an abnormal connection or passageway between two)
Insomnia (sleeplessness)
Mood swings (an extreme or rapid change in mood)
Muscle twitching
Night sweats (sweating in night)

What are the common drug interactions of Accolate and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Gastroenteritis bacterial (inflammation of stomach and intestine by bacterial infection)
Inflammatory bowel disease
Rectal haemorrhage (bleeding from anus)
Proctalgia (pain in the rectum)
Abdominal pain upper
Anxiety
Depression

20-29:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Infective exacerbation of bronchiectasis (severe infective lung disease)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pain
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pulmonary function test decreased

30-39:

Lacunar infarction (a type of stroke)
Cerebral haemorrhage (bleeding within the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Disease recurrence
Drug screen positive
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Post concussion syndrome
Road traffic accident
Traumatic brain injury (brain injury due to trauma)

40-49:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Hypoacusis (loss of hearing)
Drug ineffective
Chest pain
Insomnia (sleeplessness)
Stress
Acute respiratory failure
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

50-59:

Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Impaired healing
Leukocytosis (increased white blood cells)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pleural effusion (water on the lungs)
Radiculitis lumbosacral (inflammation of nerve root at labosacral vertebrea)
Rectal haemorrhage (bleeding from anus)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Rib fracture

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Gait disturbance
Hot flush (sudden feelings of heat)
Renal failure (kidney dysfunction)
Restlessness (not able to rest)
Vomiting
Anaemia (lack of blood)
Anger
Cardiac failure congestive

What are the existing conditions these people have? *

Pain: 14 people, 17.50%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 13 people, 16.25%
Sinobronchitis (long lasting paranasal sinusitis with repeated bronchitis): 11 people, 13.75%
Infection: 11 people, 13.75%
Diarrhea: 11 people, 13.75%
Acne (skin problems that cause pimples): 11 people, 13.75%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 12.50%
Stress And Anxiety: 7 people, 8.75%
Urinary Tract Infection: 6 people, 7.50%
High Blood Pressure: 6 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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