Accutane and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accutane (isotretinoin) and Methotrexate (methotrexate sodium). Common drug interactions include blood triglycerides increased among females and inflammatory bowel disease among males.

The phase IV clinical study analyzes what interactions people have when they take Accutane and Methotrexate. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 10, 2026

88 people who take Accutane and Methotrexate together, and have interactions are studied.

Accutane and Methotrexate drug interactions.

What are the common drug interactions of Accutane and Methotrexate, by gender? *:

female:

Blood triglycerides increased
Atelectasis (partial or complete collapse of the lung)
Anaemia (lack of blood)
Pancreatitis (inflammation of pancreas)
Drug hypersensitivity
Arthralgia (joint pain)
Blood cholesterol increased
Pain
Pulmonary tuberculosis (lungs tuberculosis)
Renal failure (kidney dysfunction)

male:

Inflammatory bowel disease
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Pain
Lip dry
Bone pain
Dizziness
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pruritus (severe itching of the skin)
Intestinal obstruction
Arthralgia (joint pain)

What are the common drug interactions of Accutane and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Inflammatory bowel disease
Dry skin
Epistaxis (bleed from the nose)
Insomnia (sleeplessness)
Irritable bowel syndrome
Lip dry
Sepsis (a severe blood infection that can lead to organ failure and death)
Suicidal ideation
Atrioventricular block second degree (heart block second degree)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

10-19:

Inflammatory bowel disease
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Irritable bowel syndrome
Anal fistula
Colitis ulcerative (inflammation of colon with ulcer)
Intestinal obstruction
Anxiety
Back pain
Gastrointestinal injury (injury to gastrointestinal tract)
Intestinal haemorrhage (bleeding from intestine)

20-29:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Balance disorder
Hidradenitis (chronic disease of a type of sweat gland)
Lymphadenopathy (disease or enlargement of lymph nodes)
Migraine (headache)
Pain
Pain of skin
Pericarditis (inflammation of the pericardium)
Pruritus (severe itching of the skin)

30-39:

Inflammatory bowel disease
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Irritable bowel syndrome
Rectal fissure (painful condition in which a cut or tear occurs in the anus)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Psoriasis (immune-mediated disease that affects the skin)
Cardiac disorder
Depression

40-49:

Colitis ulcerative (inflammation of colon with ulcer)
Depression
Inflammatory bowel disease
Hypotension (abnormally low blood pressure)
Injury
Pericardial effusion (fluid around the heart)
Pulmonary tuberculosis (lungs tuberculosis)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Drug hypersensitivity
Fungal infection

50-59:

Blood triglycerides increased
Colitis ulcerative (inflammation of colon with ulcer)
Injury
Anxiety
Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)
Blood cholesterol increased
Cardiac tamponade (fluid accumulates in heart covering)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

60+:

Inflammatory bowel disease
Colitis ulcerative (inflammation of colon with ulcer)
Intestinal obstruction
Pain in extremity
Sepsis (a severe blood infection that can lead to organ failure and death)
Small intestinal obstruction (blockage in small intestine)
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug eruption (adverse drug reaction of the skin)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 13 people, 14.77%
Psoriasis (immune-mediated disease that affects the skin): 11 people, 12.50%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 10 people, 11.36%
Joint Pain: 8 people, 9.09%
Colitis (inflammation of colon): 8 people, 9.09%
Vasculitis (inflammation of a blood vessel or blood vessels): 7 people, 7.95%
Folliculitis (infection of hair root): 7 people, 7.95%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 6.82%
Hidradenitis (chronic disease of a type of sweat gland): 6 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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