Accutane and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Accutane (isotretinoin) and Premarin (estrogens, conjugated). Common drug interactions include gastrointestinal injury among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Accutane and Premarin. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 17, 2026

52 people who take Accutane and Premarin together, and have interactions are studied.

Accutane and Premarin drug interactions.

What are the common drug interactions of Accutane and Premarin, by gender? *:

female:

Gastrointestinal injury (injury to gastrointestinal tract)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Osteopenia (a condition where bone mineral density is lower than normal)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Asthenia (weakness)
Back pain
Clostridial infection (infectious conditions by clostridium bacteria)
Dry eye (lack of adequate tears)
Large intestine perforation (hole in large intestine)

male:

Blood glucose increased
Bedridden
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Asthenia (weakness)
Blood creatinine increased
Blood thyroid stimulating hormone decreased
Blood thyroid stimulating hormone increased
Cardiac murmur (an heart sound in valve abnormality)
Chapped lips (cracking, fissuring, and peeling of the skin f lip)

What are the common drug interactions of Accutane and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depression
Blood glucose increased
Colitis ulcerative (inflammation of colon with ulcer)
Inflammatory bowel disease
Bedridden
Catatonia (unresponsive to external stimuli)
Chest pain
Cough
Dry eye (lack of adequate tears)
Intestinal haemorrhage (bleeding from intestine)

20-29:

n/a

30-39:

Abdominal pain
Hyperlipidaemia (presence of excess lipids in the blood)
Tenderness (pain or discomfort when an affected area is touched)
Vomiting

40-49:

Inflammatory bowel disease
Irritable bowel syndrome
Abscess intestinal (collections of pus-intestinal)
Acute sinusitis
Anxiety
Asthma
Atelectasis (partial or complete collapse of the lung)
Blood triglycerides increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Clostridial infection (infectious conditions by clostridium bacteria)

50-59:

Heart rate irregular
Irritable bowel syndrome
Rash pruritic (redness with itching)
Skin discolouration (change of skin colour)
Sore throat (pain or irritation of the throat)
Anxiety
Blood amylase increased
Blood triglycerides increased
Coma (state of unconsciousness lasting more than six hours)
Dry skin

60+:

Colitis ulcerative (inflammation of colon with ulcer)
Inflammatory bowel disease
Acute sinusitis
Alveolitis allergic (inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts)
Asthma
Atelectasis (partial or complete collapse of the lung)
Blood triglycerides increased
Breast cancer
Breast cyst
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Depression: 8 people, 15.38%
High Blood Pressure: 7 people, 13.46%
Menopause (end of monthly cycles in women): 6 people, 11.54%
Acne Cystic (skin problems that cause pimples): 4 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Accutane and Premarin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously