Aceon and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aceon (perindopril erbumine) and Glucophage (metformin hydrochloride). Common drug interactions include gastric disorder among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Aceon and Glucophage. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Aceon?

Aceon has active ingredients of perindopril erbumine. It is often used in high blood pressure. eHealthMe is studying from 1,785 Aceon users. Check the latest studies of Aceon.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

59 people who take Aceon and Glucophage together, and have interactions are studied.

What are the common drug interactions of Aceon and Glucophage, by gender? *:

female:

Gastric disorder (disease of stomach)
Hypokalaemia (low potassium)
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Silent myocardial infarction (a heart attack without having any symptoms)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal pain upper
Acute myocardial infarction (acute heart attack)
Anaemia (lack of blood)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)

male:

Dyspnoea (difficult or laboured respiration)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cardiac disorder
Cataract (clouding of the lens inside the eye)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Diplopia (double vision)
Eye disorder
Eyelid ptosis (falling of the upper or lower eyelid)

What are the common drug interactions of Aceon and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased

40-49:

Asthenia (weakness)
Cardiac failure congestive
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Hypochloraemia (electrolyte disturbance in which there is an abnormally low level of the chloride ion in the blood)
Hypokalaemia (low potassium)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Chest pressure sensation (feeling of pressure on chest)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Difficulty in walking
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Feeling jittery
Hepatitis c
Hepatocellular damage (liver damage)
Hydronephrosis (water inside the kidney)

60+:

Depression
Hyperkalaemia (damage to or disease of the kidney)
Anaemia (lack of blood)
Blood glucose increased
Cardiac failure
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cough
Dizziness
Dyspnoea (difficult or laboured respiration)
Emotional distress

What are the existing conditions these people have? *

Type 2 Diabetes: 4 people, 6.78%
Pain: 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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