Acetaminophen and codeine phosphate and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate) and Cymbalta (duloxetine hydrochloride). Common drug interactions include agitation among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and codeine phosphate and Cymbalta. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

On Aug, 01, 2026

25 people who take Acetaminophen and codeine phosphate and Cymbalta together, and have interactions are studied.

Acetaminophen and codeine phosphate and Cymbalta drug interactions.

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Cymbalta, by gender? *:

female:

Agitation (state of anxiety or nervous excitement)
Chest pain
Headache (pain in head)
Insomnia (sleeplessness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Activities of daily living impaired
Hyperreflexia (overactive or over responsive reflexes)
Muscular weakness (muscle weakness)
Neck pain
Pain in extremity

male:

Cellulitis (infection under the skin)
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Iron deficiency anaemia
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Skin ulcer
Venous insufficiency (poor circulation of blood caused by damaged or enlarged veins)

What are the common drug interactions of Acetaminophen And Codeine Phosphate and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Neuralgia (pain in one or more nerves)
Hyperaesthesia
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Insomnia (sleeplessness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

Activities of daily living impaired
Agitation (state of anxiety or nervous excitement)
Chest pain
Hyperreflexia (overactive or over responsive reflexes)
Muscular weakness (muscle weakness)
Neck pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Hepatitis (inflammation of the liver)

40-49:

Agitation (state of anxiety or nervous excitement)
Headache (pain in head)
Insomnia (sleeplessness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Red blood cell sedimentation rate increased
Weight increased

50-59:

Anaphylactic reaction (serious allergic reaction)
Bone marrow failure
Cellulitis (infection under the skin)
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Drug effect decreased
Erosive oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time)
Fall
Femur fracture
Gastric antral vascular ectasia (blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding)
Gastric ulcer (stomach ulcer)

60+:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Suicidal ideation
Death
Decreased interest
Dehydration (dryness resulting from the removal of water)
Diabetic complication
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Emotional disorder

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 20.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 12.00%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 12.00%
Osteoporosis (bones weak and more likely to break): 3 people, 12.00%
High Blood Pressure: 3 people, 12.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 12.00%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 12.00%
Diabetes: 3 people, 12.00%
Stress And Anxiety: 2 people, 8.00%
Migraine (headache): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and codeine phosphate and Cymbalta?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously