Acetaminophen and Daypro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen (acetaminophen) and Daypro (oxaprozin). Common drug interactions include oedema peripheral among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and Daypro. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,078 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Daypro?

Daypro has active ingredients of oxaprozin. It is often used in osteoarthritis. eHealthMe is studying from 2,883 Daypro users. Check the latest studies of Daypro.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

38 people who take Acetaminophen and Daypro together, and have interactions are studied.

Acetaminophen and Daypro drug interactions.

What are the common drug interactions of Acetaminophen and Daypro, by gender? *:

female:

Oedema peripheral (superficial swelling)
Arthralgia (joint pain)
Cough
Dyspnoea (difficult or laboured respiration)
Feeling hot
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pneumonia
Anaemia (lack of blood)
Asthenia (weakness)
Bone disorder

male:

Fall
Cervical vertebral fracture
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Rigors (an episode of shaking or exaggerated shivering)
Small intestinal obstruction (blockage in small intestine)
Urinary retention (the inability to completely or partially empty the bladder)
Abdominal discomfort
Abscess (pus)
Actinomyces test positive
Anaphylactic reaction (serious allergic reaction)

What are the common drug interactions of Acetaminophen and Daypro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Completed suicide (act of taking one's own life)
Fall
Gastric haemorrhage (bleeding stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Glomerulonephritis membranoproliferative (a type of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basement membrane (gbm) thickening)
Sinusitis (inflammation of sinus)
Suicidal ideation

30-39:

Cardiac flutter (abnormal heart rhythm)
Diarrhoea
Erythema (redness of the skin)
Feeling hot
Heart rate increased
Infusion site rash
Muscle tightness
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting

40-49:

Allergy to vaccine
Anxiety
Application site warmth
Atrioventricular block (heart block)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood pressure increased
Blood urine present
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Fatigue (feeling of tiredness)
Infusion site erythema (reddening of the skin at infusion site)

50-59:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sinusitis (inflammation of sinus)
Spinal osteoarthritis (joint cartilage loss in spine)
Urinary retention (the inability to completely or partially empty the bladder)
Abdominal discomfort
Abscess (pus)
Actinomyces test positive
Alopecia (absence of hair from areas of the body)

60+:

Anaemia (lack of blood)
Fall
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
International normalised ratio increased
Intervertebral disc degeneration (spinal disc degeneration)
Memory impairment
Obesity (having too much body fat)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 18.42%
High Blood Pressure: 6 people, 15.79%
Inflammation: 5 people, 13.16%
Infection: 5 people, 13.16%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 13.16%
Depression: 5 people, 13.16%
Metastases To Bone (cancer spreads to bone): 4 people, 10.53%
Breast Cancer: 4 people, 10.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.89%
Immunodeficiency: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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