Acetaminophen and Macitentan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen (acetaminophen) and Macitentan (macitentan). Common drug interactions include oedema among females and atrial flutter among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and Macitentan. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

On Jul, 20, 2026

46 people who take Acetaminophen and Macitentan together, and have interactions are studied.

Acetaminophen and Macitentan drug interactions.

What are the common drug interactions of Acetaminophen and Macitentan, by gender? *:

female:

Oedema (fluid collection in tissue)
Pulmonary veno-occlusive disease (obstructive disease of the pulmonary veins)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Respiratory distress (difficulty in breathing)
Right atrial pressure increased
Right ventricular systolic pressure increased
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Swelling
Uterine haemorrhage (uterine bleeding)
Weight increased

male:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
C-reactive protein increased
Abdominal distension
Dyspnoea (difficult or laboured respiration)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Abdominal pain
Arthralgia (joint pain)
Device occlusion
Diarrhoea
Disease progression

What are the common drug interactions of Acetaminophen and Macitentan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hyperthyroidism (over activity of the thyroid gland)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Thrombocytopenia (decrease of platelets in blood)
Weight decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)
Gingival pain (gum pain)
Haemorrhage (bleeding)
Swelling
Uterine haemorrhage (uterine bleeding)

20-29:

Device occlusion

30-39:

Joint swelling
Rash
White blood cell count decreased

40-49:

Vomiting
Haemorrhage (bleeding)
Flushing (the warm, red condition of human skin)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Arrhythmia (irregular heartbeat)
Cardiorenal syndrome (kidney failure and heart failure)
Chest pain
Device related infection
Dysmenorrhoea (painful menstruation)
Epistaxis (bleed from the nose)

50-59:

Ascites (accumulation of fluid in the abdominal cavity)
Oedema peripheral (superficial swelling)
Fluid retention (an abnormal accumulation of fluid in the blood)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Abdominal distension
Brain natriuretic peptide increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus inadequate control
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

60+:

Pneumonia
Hypotension (abnormally low blood pressure)
Renal impairment (severely reduced kidney function)
Acute respiratory failure
Upper respiratory tract infection
Dizziness
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 42 people, 91.30%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 15 people, 32.61%
Nausea (feeling of having an urge to vomit): 12 people, 26.09%
High Blood Pressure: 10 people, 21.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 19.57%
Hypokalemia (low potassium): 9 people, 19.57%
Dyspnea (difficult or laboured breathing): 8 people, 17.39%
Oedema (fluid collection in tissue): 8 people, 17.39%
Indigestion: 8 people, 17.39%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 7 people, 15.22%

* Approximation only. Some reports may have incomplete information.

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