Acetaminophen and Wegovy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Acetaminophen (acetaminophen) and Wegovy (semaglutide). Common drug interactions include nausea among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Acetaminophen and Wegovy. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Wegovy?

Wegovy has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 4,886 Wegovy users. Check the latest studies of Wegovy.

On Aug, 12, 2026

32 people who take Acetaminophen and Wegovy together, and have interactions are studied.

Acetaminophen and Wegovy drug interactions.

What are the common drug interactions of Acetaminophen and Wegovy, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Vomiting
Dizziness
Sinusitis (inflammation of sinus)
Diarrhoea
Fatigue (feeling of tiredness)
Syncope (loss of consciousness with an inability to maintain postural tone)
Blood glucose decreased
Diplopia (double vision)

male:

Dyspnoea (difficult or laboured respiration)
Leukopenia (less number of white blood cells in blood)
Hypervolaemia (abnormally increased volume of blood)
Pneumonia
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Vomiting
Abdominal pain
Constipation
Erythema (redness of the skin)
Heart rate increased

What are the common drug interactions of Acetaminophen and Wegovy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)

30-39:

Loss of consciousness
Sternal fracture
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Hypophagia (reduced food intake)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Retching (strong involuntary effort to vomit)
Vomiting

40-49:

Constipation
Diarrhoea
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypertension (high blood pressure)
Infusion site discomfort
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Infusion site haemorrhage (bleeding from infusion site)
Infusion site oedema (swelling from excessive accumulation of watery fluid from infusion site)

50-59:

Vomiting
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)
Irritable bowel syndrome
Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Fatigue (feeling of tiredness)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Neuropathy peripheral (surface nerve damage)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)
Blindness unilateral
Feeding disorder (when children refuse to eat certain food groups)
Fluid intake reduced

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 12.50%
High Blood Cholesterol: 4 people, 12.50%
Depression: 4 people, 12.50%
Asthma: 4 people, 12.50%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 9.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.38%
Seasonal Allergy (allergic condition due to certain season): 2 people, 6.25%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 2 people, 6.25%
Multifocal Motor Neuropathy (a progressively worsening condition where muscles in the extremities gradually weaken): 2 people, 6.25%
Metabolic Disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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