Actigall and Fosamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actigall (ursodiol) and Fosamax (alendronate sodium). Common drug interactions include procedural pain among females and ankle fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Actigall and Fosamax. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Actigall?

Actigall has active ingredients of ursodiol. It is often used in gallstones. eHealthMe is studying from 2,162 Actigall users. Check the latest studies of Actigall.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 105,452 Fosamax users. Check the latest studies of Fosamax.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

78 people who take Actigall and Fosamax together, and have interactions are studied.

What are the common drug interactions of Actigall and Fosamax, by gender? *:

female:

Procedural pain
Asthenia (weakness)
Renal injury (kidney injury)
Back pain
Fatigue (feeling of tiredness)
Influenza
Oestrogen receptor assay positive
Stress
Deformity (disfigurement)
Hepatitis (inflammation of the liver)

male:

Ankle fracture
Cellulitis (infection under the skin)
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Colon cancer
Cough
Increased upper airway secretion
Joint dislocation (a joint position is changed from normal position)
Local swelling (swelling at the site of some application of substance or injury)
Oropharyngeal pain

What are the common drug interactions of Actigall and Fosamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dyspnoea (difficult or laboured respiration)
Chest discomfort
Cystic fibrosis (disease of the secretary glands)
Fatigue (feeling of tiredness)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

30-39:

Renal failure (kidney dysfunction)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac arrest
Cardiomegaly (increased size of heart than normal)
Chronic kidney disease
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dizziness
Dyspnoea (difficult or laboured respiration)
Grunting (abnormal, short, deep, hoarse sounds in exhalation that often accompany severe chest pain)

40-49:

Anaemia (lack of blood)
Nausea (feeling of having an urge to vomit)
Pneumonia viral
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory syncytial virus infection (viral disease of respiratory system)
Sinusitis (inflammation of sinus)
Vomiting

50-59:

Joint dislocation (a joint position is changed from normal position)
Peripheral swelling
Oedema peripheral (superficial swelling)
Chronic kidney disease
Renal injury (kidney injury)
Colon cancer
Cough
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Increased upper airway secretion

60+:

Depression
Hot flush (sudden feelings of heat)
Stress
Asthenia (weakness)
Deformity (disfigurement)
Hepatitis (inflammation of the liver)
Back pain
Fatigue (feeling of tiredness)
Aortic valve stenosis (narrowing of the aortic valve)
Breast cancer

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 8.97%
Joint Swelling: 6 people, 7.69%
Indigestion: 6 people, 7.69%
Thyroid Diseases: 5 people, 6.41%
Sleep Disorder: 5 people, 6.41%
Sinusitis (inflammation of sinus): 5 people, 6.41%
Peripheral Swelling: 4 people, 5.13%
Cystic Fibrosis (disease of the secretary glands): 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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