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Activase and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activase (alteplase) and Ibuprofen (ibuprofen). Common drug interactions include hypotension among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Activase and Ibuprofen. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

On Jul, 24, 2026

77 people who take Activase and Ibuprofen together, and have interactions are studied.

Activase and Ibuprofen drug interactions.

What are the common drug interactions of Activase and Ibuprofen, by gender? *:

female:

  1. Hypotension (abnormally low blood pressure)
  2. Protein total decreased
  3. Blood alkaline phosphatase increased
  4. Blood pressure fluctuation
  5. Dyspnoea (difficult or laboured respiration)
  6. Infusion related reaction
  7. Aspartate aminotransferase increased
  8. Blood glucose increased
  9. Blood lactate dehydrogenase increased
  10. Blood phosphorus decreased

male:

  1. Pyrexia (fever)
  2. Fatigue (feeling of tiredness)
  3. Bone density decreased
  4. Bone loss
  5. Bone pain
  6. Erythema (redness of the skin)
  7. Vision blurred
  8. Apathy
  9. Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
  10. Bone neoplasm malignant (cancer of bone)

What are the common drug interactions of Activase and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Catheter site pain
  2. Chest injury
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Dermatitis diaper (diaper rash is a common form of inflamed skin)
  5. Device occlusion
  6. Diarrhoea
  7. Erythema (redness of the skin)
  8. Fall
  9. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
  10. Head injury

10-19:

  1. Pyrexia (fever)
  2. Abdominal abscess (collection of pus in abdomen)
  3. Anastomotic leak
  4. Arthralgia (joint pain)
  5. Asthenia (weakness)
  6. Cardiomyopathy (weakening of the heart muscle)
  7. Constipation
  8. Dyspnoea (difficult or laboured respiration)
  9. Enterobacter pneumonia (lung inflammation caused by bacteria of the family enterobacteriaceae)
  10. Epistaxis (bleed from the nose)

20-29:

  1. Abdominal discomfort
  2. Abdominal distension
  3. Adverse drug reaction
  4. Anaemia (lack of blood)
  5. Blood creatine phosphokinase increased
  6. Blood pressure increased
  7. Death
  8. Dehydration (dryness resulting from the removal of water)
  9. Disease progression
  10. Hyperhidrosis (abnormally increased sweating)

30-39:

  1. Blood pressure fluctuation
  2. Fall
  3. Infusion related reaction
  4. Nausea (feeling of having an urge to vomit)
  5. Vomiting
  6. Catheter site infection (infection at the site of insertion)
  7. Chest discomfort
  8. Chills (felling of cold)
  9. Erythema (redness of the skin)
  10. Fatigue (feeling of tiredness)

40-49:

  1. Dyspnoea (difficult or laboured respiration)
  2. Fatigue (feeling of tiredness)
  3. Weight decreased
  4. Arthralgia (joint pain)
  5. Insomnia (sleeplessness)
  6. Pyrexia (fever)
  7. Apathy
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  9. Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
  10. Bacterial infection

50-59:

  1. Cerebral haemorrhage (bleeding within the brain)
  2. Cholecystitis chronic (long lasting infection of gallbladder)
  3. Constipation
  4. Diarrhoea
  5. Dizziness
  6. Drug hypersensitivity
  7. Hair colour changes
  8. Humerus fracture (injury to the upper arm bone)
  9. Hypokalaemia (low potassium)
  10. Injury

60+:

  1. Pyrexia (fever)
  2. Alanine aminotransferase increased
  3. Blood glucose increased
  4. Blood lactate dehydrogenase increased
  5. Blood phosphorus decreased
  6. Blood triglycerides increased
  7. Blood urea decreased
  8. Blood uric acid decreased
  9. Carbon dioxide decreased
  10. Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 9 people, 11.69%
  2. Stress And Anxiety: 8 people, 10.39%
  3. Breast Cancer: 7 people, 9.09%
  4. Acute Myocardial Infarction (acute heart attack): 7 people, 9.09%
  5. Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 6 people, 7.79%
  6. Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 4 people, 5.19%
  7. Hypersensitivity: 4 people, 5.19%
  8. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 5.19%
  9. Constipation: 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

Do you take Activase and Ibuprofen?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Activase and Ibuprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Activase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ibuprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Activase and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ibuprofen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on alteplase and ibuprofen (the active ingredients of Activase and Ibuprofen, respectively), and Activase and Ibuprofen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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