Activella and Chantix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Activella (estradiol; norethindrone acetate) and Chantix (varenicline tartrate). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Activella and Chantix. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

On Jul, 10, 2026

33 people who take Activella and Chantix together, and have interactions are studied.

Activella and Chantix drug interactions.

What are the common drug interactions of Activella and Chantix, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Pain in extremity
Fistula (an abnormal connection or passageway between two)
Haematuria (presence of blood in urine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypoaesthesia (reduced sense of touch or sensation)
Hypophosphatasia (metabolic bone disease)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Impaired healing
Implant site swelling

male:

n/a

What are the common drug interactions of Activella and Chantix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Cough
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Insomnia (sleeplessness)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Lordosis (outward curve of the back bone)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

50-59:

Hot flush (sudden feelings of heat)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Anaemia (lack of blood)
Anxiety
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chest pain
Dyslipidaemia (abnormal amount of lipids)
Dysplasia (enlargement of an organ or tissue)

60+:

Chronic kidney disease
Abnormal dreams
Nephrolithiasis (calculi in the kidneys)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Stress
Alopecia (absence of hair from areas of the body)
Anxiety
Depression
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 6 people, 18.18%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 18.18%
Depression: 6 people, 18.18%
Stress And Anxiety: 5 people, 15.15%
High Blood Cholesterol: 5 people, 15.15%
High Blood Pressure: 4 people, 12.12%
Hypersensitivity: 4 people, 12.12%
Headache (pain in head): 4 people, 12.12%
Gastric Ulcer (stomach ulcer): 4 people, 12.12%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 12.12%

* Approximation only. Some reports may have incomplete information.

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