Actonel and Exjade drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actonel (risedronate sodium) and Exjade (deferasirox). Common drug interactions include joint swelling among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Actonel and Exjade. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Exjade?

Exjade has active ingredients of deferasirox. It is often used in iron overload. eHealthMe is studying from 29,456 Exjade users. Check the latest studies of Exjade.

On Jul, 11, 2026

100 people who take Actonel and Exjade together, and have interactions are studied.

What are the common drug interactions of Actonel and Exjade, by gender? *:

female:

Joint swelling
Nasopharyngitis (inflammation of the nasopharynx)
Otitis externa (external ear infection)
Salivary gland calculus (stone in salivary gland)
Thyroid mass
Vertigo
Pain
Blood pressure increased
Haemoglobin decreased
Malignant neoplasm progression (cancer tumour came back)

male:

Diarrhoea
Insomnia (sleeplessness)
Serum ferritin increased
Abdominal discomfort
Dental caries
Toothache (tooth pain)
Platelet count decreased
Tibia fracture (fracture of lower leg bone)
Abasia (inability to walk)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the common drug interactions of Actonel and Exjade, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Back pain
Hepatic enzyme increased
Nephrolithiasis (calculi in the kidneys)
Pain
Abdominal pain upper
Abdominal pain
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Atrial hypertrophy (a condition where the left atrium or right atrium of the heart is larger than would be expected)
Blood creatine increased
Blood magnesium decreased

40-49:

Insomnia (sleeplessness)
Oedema peripheral (superficial swelling)
Pruritus generalised (generalized itching)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Stress
Urticaria (rash of round, red welts on the skin that itch intensely)
Diarrhoea
Oral candidiasis (fungal infection of mouth)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Serum ferritin increased

50-59:

Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Influenza
Joint stiffness
Joint swelling
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Otitis externa (external ear infection)
Salivary gland calculus (stone in salivary gland)
Serum ferritin increased

60+:

Diarrhoea
Sepsis (a severe blood infection that can lead to organ failure and death)
Blood iron increased
Burning sensation
Dysphonia (speech disorder attributable to a disorder of phonation)
Myalgia (muscle pain)
Pharyngeal erythema (pharyngeal redness)
Pruritus generalised (generalized itching)
Blood pressure increased
Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 36 people, 36.00%
Polychondritis (progressive inflammation of cartilage and other connective tissue): 10 people, 10.00%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 10 people, 10.00%
Pain: 6 people, 6.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 6.00%
Anaemia (lack of blood): 6 people, 6.00%
Stress And Anxiety: 5 people, 5.00%
Serum Ferritin Increased: 5 people, 5.00%
Indigestion: 5 people, 5.00%
Aplastic Anemia: 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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