Actos and Yasmin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Actos (pioglitazone hydrochloride) and Yasmin (drospirenone; ethinyl estradiol). Common drug interactions include gastrointestinal haemorrhage among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Actos and Yasmin. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Yasmin?

Yasmin has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 48,855 Yasmin users. Check the latest studies of Yasmin.

On Jul, 19, 2026

58 people who take Actos and Yasmin together, and have interactions are studied.

What are the common drug interactions of Actos and Yasmin, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Heart rate irregular
Intervertebral disc disorder (spinal disc disorder)
Joint dislocation (a joint position is changed from normal position)
Laryngeal injury
Nervousness
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Ulcer haemorrhage (bleeding ulcer)
Ulna fracture (fracture inside bone)

male:

Pain
Injury
Thrombosis (formation of a blood clot inside a blood vessel)
Asthenia (weakness)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Chest pain
Gallbladder disorder
Bladder cancer
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Cardiac disorder

What are the common drug interactions of Actos and Yasmin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Chest pain
Emotional distress
Injury
Muscle spasms (muscle contraction)
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Gallbladder injury
Nausea (feeling of having an urge to vomit)

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pain
Dyspepsia (indigestion)
Abdominal distension
Biliary fibrosis
Cholecystitis acute (rapid infection of gallbladder)
Cholecystitis chronic (long lasting infection of gallbladder)
Diarrhoea
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Abdominal pain upper

30-39:

Abnormal loss of weight
Arthralgia (joint pain)
Body height decreased
Body temperature decreased
Drug ineffective
Fear of disease
Heart rate irregular
Intervertebral disc disorder (spinal disc disorder)
Laryngeal injury
Nervousness

40-49:

Pulmonary embolism (blockage of the main artery of the lung)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholecystitis chronic (long lasting infection of gallbladder)
Depression
Fear

50-59:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholecystitis chronic (long lasting infection of gallbladder)
Injury
Pulmonary embolism (blockage of the main artery of the lung)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
General physical health deterioration (weak health status)
Pain
Blood disorder

60+:

Injury
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Bladder squamous cell carcinoma stage unspecified (bladder squamous cell cancer stage unspecified)
Blood glucose increased
Blood triglycerides increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
General physical health deterioration (weak health status)
Hypertension (high blood pressure)
Joint dislocation (a joint position is changed from normal position)

What are the existing conditions these people have? *

Pain: 10 people, 17.24%
Depression: 10 people, 17.24%
Acne (skin problems that cause pimples): 9 people, 15.52%
High Blood Pressure: 8 people, 13.79%
Premenstrual Syndrome: 7 people, 12.07%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 7 people, 12.07%
Constipation: 6 people, 10.34%
Type 2 Diabetes: 6 people, 10.34%
Multiple Allergies (allergy to multiple agents): 5 people, 8.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and Yasmin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously