Adapalene and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adapalene (adapalene) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include ascites among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Adapalene and Flexeril. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Adapalene?

Adapalene has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 174,662 Adapalene users. Check the latest studies of Adapalene.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 20, 2026

36 people who take Adapalene and Flexeril together, and have interactions are studied.

Adapalene and Flexeril drug interactions.

What are the common drug interactions of Adapalene and Flexeril, by gender? *:

female:

Ascites (accumulation of fluid in the abdominal cavity)
Headache (pain in head)
Breath odour
Cachexia (loss of weight)
Compression fracture (fracture due to pressure caused by injury)
Disability
Dry eye (lack of adequate tears)
Dry mouth
Duodenitis (inflammation of the duodenum)
Dyspnoea (difficult or laboured respiration)

male:

Drug hypersensitivity
Migraine (headache)
Influenza

What are the common drug interactions of Adapalene and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Erythema (redness of the skin)
Skin burning sensation
Dry skin
Hypersensitivity
Skin erosion (a discontinuity of the skin)
Skin irritation

30-39:

Erythema (redness of the skin)
Influenza
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pruritus (severe itching of the skin)
Rash
Skin burning sensation
Skin exfoliation (removal of the oldest dead skin cells)

40-49:

Erythema (redness of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Skin exfoliation (removal of the oldest dead skin cells)
Skin tightness
Systemic lupus erythematosus rash (an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue and causes the rashes)
Urticaria (rash of round, red welts on the skin that itch intensely)
Drug ineffective
Erythema (redness of the skin)
Skin burning sensation
Skin irritation
Dry skin
Overdose

60+:

Overdose
Skin lesion

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 16 people, 44.44%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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