Adapalene and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adapalene (adapalene) and Flonase (fluticasone propionate). Common drug interactions include dry skin among females and erythema among males.

The phase IV clinical study analyzes what interactions people have when they take Adapalene and Flonase. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Adapalene?

Adapalene has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 174,662 Adapalene users. Check the latest studies of Adapalene.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

On Jul, 10, 2026

95 people who take Adapalene and Flonase together, and have interactions are studied.

Adapalene and Flonase drug interactions.

What are the common drug interactions of Adapalene and Flonase, by gender? *:

female:

Dry skin
Skin burning sensation
Erythema (redness of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Skin irritation
Overdose
Pruritus (severe itching of the skin)
Pain of skin
Rash
Rash papular (redness with papule)

male:

Erythema (redness of the skin)
Skin burning sensation
Rash
Renal disorder (kidney disease)
Renal impairment (severely reduced kidney function)
Drug ineffective
Overdose
Bone density decreased
Pain of skin
Rash erythematous (redness of the skin)

What are the common drug interactions of Adapalene and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Skin warm
Acne cystic (skin problems that cause pimples)
Asthma
Chemical burn of skin
Drug effect decreased
Hypersensitivity
Seborrhoea (a disease of the sebaceous glands characterized by excessive secretion of sebum)
Skin discolouration (change of skin colour)
Skin discomfort (skin pain/irritation)
Skin fissures (a crack in the skin)

20-29:

Erythema (redness of the skin)
Skin burning sensation
Skin irritation
Dry skin
Hypersensitivity
Overdose
Pain of skin
Rash
Rash erythematous (redness of the skin)
Rash papular (redness with papule)

30-39:

Pain of skin
Erythema (redness of the skin)
Rash papular (redness with papule)
Urticaria (rash of round, red welts on the skin that itch intensely)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Rash
Skin burning sensation
Pruritus (severe itching of the skin)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

40-49:

Dry skin
Skin burning sensation
Erythema (redness of the skin)
Overdose
Pruritus (severe itching of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Drug ineffective
Pain of skin
Rash
Rash pustular (redness with pustules)

50-59:

Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Renal disorder (kidney disease)
Drug ineffective
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Tubulointerstitial nephritis and uveitis syndrome (a rare autoimmune disease a form of nephritis affecting the interstitium of the kidneys surrounding the tubules along with inflammation of the middle layer of the eye)
Blood pressure increased

60+:

Skin burning sensation
Dry skin
Erythema (redness of the skin)
Eye irritation
Rash macular (small, flat red spots)

What are the existing conditions these people have? *

Hypersensitivity: 8 people, 8.42%
Skin Hyperpigmentation (disorders affect the colour of your skin): 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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