Adderall and Differin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Differin (adapalene). Common drug interactions include bronchitis among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Differin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

On Jul, 07, 2026

22 people who take Adderall and Differin together, and have interactions are studied.

Adderall and Differin drug interactions.

What are the common drug interactions of Adderall and Differin, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Chest discomfort
Claustrophobia (fear of having no escape and being closed in small spaces)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Delayed sleep phase
Dry skin

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dizziness
Fatigue (feeling of tiredness)
Gallbladder disorder
General physical health deterioration (weak health status)

What are the common drug interactions of Adderall and Differin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Chest pain
Complication of device insertion
Dizziness
Fatigue (feeling of tiredness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Overdose
Painful respiration
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)

20-29:

Anxiety
Emotional distress
Pain
Tooth loss
Suicidal ideation
Bone density decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

30-39:

n/a

40-49:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fall
Sinusitis (inflammation of sinus)
Spinal fracture (fracture in one of vertebrae)
Abdominal discomfort
Coeliac disease (simple food intolerance)
Multiple fractures
Nausea (feeling of having an urge to vomit)

50-59:

n/a

60+:

Drug ineffective

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 45.45%
Immunodeficiency: 3 people, 13.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 13.64%
Hiv Infection: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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