Adderall and Lioresal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Lioresal (baclofen). Common drug interactions include wound infection among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Lioresal. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

What is Lioresal?

Lioresal has active ingredients of baclofen. It is often used in multiple sclerosis. eHealthMe is studying from 20,572 Lioresal users. Check the latest studies of Lioresal.

On Jul, 16, 2026

81 people who take Adderall and Lioresal together, and have interactions are studied.

Adderall and Lioresal drug interactions.

What are the common drug interactions of Adderall and Lioresal, by gender? *:

female:

Wound infection
Adjustment disorder with anxiety
Anal cancer
Anal haemorrhage
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve replacement
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Colorectal cancer (colon cancer or bowel cancer)
Constipation
Diplopia (double vision)

male:

Headache (pain in head)
Urinary retention (the inability to completely or partially empty the bladder)
Tremor (trembling or shaking movements in one or more parts of your body)
Drug dependence
Muscle spasms (muscle contraction)
Asthenia (weakness)
Drug intolerance (drug sensitivity)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hyperaesthesia
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Adderall and Lioresal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Cardiac arrest

30-39:

Muscle spasms (muscle contraction)
Pain
Anxiety
Asthenia (weakness)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hyperaesthesia
Hyperhidrosis (abnormally increased sweating)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Muscle tightness
Nausea (feeling of having an urge to vomit)

40-49:

Urinary tract infection
Muscle spasms (muscle contraction)
Catheter site infection (infection at the site of insertion)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Impaired healing
Muscular weakness (muscle weakness)
Wound infection
Diplopia (double vision)
Dizziness

50-59:

Stress
Uterine cyst
Vitamin d deficiency
Weight increased
Headache (pain in head)
Myalgia (muscle pain)
Urinary retention (the inability to completely or partially empty the bladder)
Device failure
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Knee arthroplasty

60+:

Urinary tract infection
Adjustment disorder with anxiety
Dysuria (painful or difficult urination)
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Gastrointestinal neoplasm (cancer tumour of digestive tract)
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Intervertebral disc protrusion (spinal disc protrusion)

What are the existing conditions these people have? *

Pain: 18 people, 22.22%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 16 people, 19.75%
Muscle Spasms (muscle contraction): 16 people, 19.75%
Gait Disturbance: 10 people, 12.35%
Drowsiness: 10 people, 12.35%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 11.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 9.88%
Sleep Disorder: 7 people, 8.64%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 7.41%
Nausea (feeling of having an urge to vomit): 6 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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