Adderall and Midol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Midol (ibuprofen). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Midol. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

What is Midol?

Midol has active ingredients of ibuprofen. It is often used in painful menstrual periods. eHealthMe is studying from 2,635 Midol users. Check the latest studies of Midol.



On Jul, 02, 2026

29 people who take Adderall and Midol together, and have interactions are studied.

Adderall and Midol drug interactions.

What are the common drug interactions of Adderall and Midol, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Muscle spasms (muscle contraction)
  3. Dizziness
  4. Dry mouth
  5. Fatigue (feeling of tiredness)
  6. Hair colour changes
  7. Incontinence (lack of moderation or self-control)
  8. Anxiety
  9. Constipation
  10. Diarrhoea

male:

n/a

What are the common drug interactions of Adderall and Midol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
  2. Headache (pain in head)
  3. Mydriasis (a dilation of the pupil)
  4. Photophobia (extreme sensitivity to light)
  5. Visual disturbance
  6. Visual impairment

20-29:

  1. Drug ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Hospitalisation
  4. Influenza
  5. Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
  6. Migraine (headache)
  7. Muscular weakness (muscle weakness)
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  9. Peripheral swelling
  10. Skin burning sensation

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 79.31%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 19 people, 65.52%
  3. Drowsiness: 6 people, 20.69%
  4. Sinus Disorder (disease of sinus): 3 people, 10.34%
  5. Sinusitis (inflammation of sinus): 2 people, 6.90%
  6. Birth Control: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Adderall and Midol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Adderall and Midol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Adderall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Midol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Adderall and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Midol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate and ibuprofen (the active ingredients of Adderall and Midol, respectively), and Adderall and Midol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: