Adrenal and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adrenal (adrenal extract) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include sepsis among females and adrenal disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Adrenal and Flexeril. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Adrenal?

Adrenal has active ingredients of adrenal extract. eHealthMe is studying from 850 Adrenal users. Check the latest studies of Adrenal.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 11, 2026

12 people who take Adrenal and Flexeril together, and have interactions are studied.

What are the common drug interactions of Adrenal and Flexeril, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Allergy to animal
Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Constipation
Disturbance in attention
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sinusitis (inflammation of sinus)

male:

Adrenal disorder
Anorgasmia (type of sexual dysfunction in which a person cannot achieve orgasm, even with adequate stimulation)
Feeling of despair
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
General physical health deterioration (weak health status)
Genital hypoaesthesia (sensation loss of genital)
Insomnia (sleeplessness)
Loss of employment
Loss of libido (loss of sexual urge)
Mania (a state of abnormally elevated or irritable mood)

What are the common drug interactions of Adrenal and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Adrenal disorder
Anorgasmia (type of sexual dysfunction in which a person cannot achieve orgasm, even with adequate stimulation)
Anxiety
Apathy
Blood oestrogen increased
Depression
Educational problem
Ejaculation failure
Endocrine disorder (endocrine diseases are disorders of the endocrine system)
Erectile dysfunction

40-49:

Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)
Abasia (inability to walk)
Anal abscess
Benign neoplasm (benign (non-cancerous) tumour)
Cerebrospinal fluid leakage
Csf pressure increased
Genital abscess (build up of pus in genital)
Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)

50-59:

Abdominal pain
Constipation
Nausea (feeling of having an urge to vomit)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 25.00%
Type 2 Diabetes: 2 people, 16.67%
Hypotension (abnormally low blood pressure): 2 people, 16.67%
Insomnia (sleeplessness): 2 people, 16.67%
Weight Decreased: 2 people, 16.67%
Renal Disorder (kidney disease): 1 person, 8.33%
Pain: 1 person, 8.33%
Neuropathy Peripheral (surface nerve damage): 1 person, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%
Sleep Disorder: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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