Aldactazide and Pantoprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactazide (hydrochlorothiazide; spironolactone) and Pantoprazole (pantoprazole sodium). Common drug interactions include cerebrovascular accident among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactazide and Pantoprazole. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 285,165 Pantoprazole users. Check the latest studies of Pantoprazole.

On Jul, 14, 2026

42 people who take Aldactazide and Pantoprazole together, and have interactions are studied.

Aldactazide and Pantoprazole drug interactions.

What are the common drug interactions of Aldactazide and Pantoprazole, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)
Gastrointestinal infection (infection of stomach and intestine)
Leukopenia (less number of white blood cells in blood)
Memory impairment
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Platelet count decreased
Pulmonary oedema (fluid accumulation in the lungs)

male:

Drug ineffective
Chronic kidney disease
Atelectasis (partial or complete collapse of the lung)
Atypical mycobacterium test positive
Bacteraemia (presence of bacteria in the blood)
Brain death
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain injury
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the common drug interactions of Aldactazide and Pantoprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Venoocclusive disease (small veins in the liver are obstructed)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pancreatitis acute (sudden inflammation of pancreas)
Hospitalisation
Nausea (feeling of having an urge to vomit)
Vomiting
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Memory impairment
Road traffic accident
Coronary artery embolism (blockage of artery of heart)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Weight increased

50-59:

Blood triglycerides increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cardiomyopathy (weakening of the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Pulmonary oedema (fluid accumulation in the lungs)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Balance disorder
Benign prostatic hyperplasia (benign enlargement of the prostate)
Cardiovascular disorder (heart diseases)

60+:

Asthenia (weakness)
Confusional state
Anaemia (lack of blood)
Leukopenia (less number of white blood cells in blood)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal failure (kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)
Tremor (trembling or shaking movements in one or more parts of your body)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Abdominal discomfort

What are the existing conditions these people have? *

Diabetes: 9 people, 21.43%
Pain: 7 people, 16.67%
High Blood Cholesterol: 6 people, 14.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 11.90%
Nausea (feeling of having an urge to vomit): 4 people, 9.52%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 9.52%
Rickets (softening of bones): 3 people, 7.14%
Partial Lipodystrophy (bodily loss or redistribution of fat tissue): 3 people, 7.14%
Ovarian Cancer (cancer of ovary): 3 people, 7.14%
Multiple Myeloma (cancer of the plasma cells): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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