Aldactazide and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactazide (hydrochlorothiazide; spironolactone) and Profen (ibuprofen). Common drug interactions include muscle spasms among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactazide and Profen. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,312 Profen users. Check the latest studies of Profen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

54 people who take Aldactazide and Profen together, and have interactions are studied.

Aldactazide and Profen drug interactions.

What are the common drug interactions of Aldactazide and Profen, by gender? *:

female:

Muscle spasms (muscle contraction)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Pelvic pain
Peripheral swelling
Pneumonia
Rash
Renal failure acute (rapid kidney dysfunction)
Restlessness (not able to rest)
Activities of daily living impaired
Anxiety

male:

Chronic kidney disease
Renal injury (kidney injury)
Device related infection
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Acute respiratory failure
Ankle fracture
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Aldactazide and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Oxygen saturation decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)
Respiratory rate increased (excess breathing rate/min)
Cardiac arrest
Hyperkalaemia (damage to or disease of the kidney)
Respiratory distress (difficulty in breathing)
Respiratory tract infection
Tracheitis (an inflammation of the trachea)

10-19:

Catheter site pain
Catheter site pruritus (itching at the site)
Device related infection
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Nasopharyngitis (inflammation of the nasopharynx)
Pyrexia (fever)
Septic shock (shock due to blood infection)

20-29:

n/a

30-39:

n/a

40-49:

Vomiting
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Multiple drug overdose
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Activities of daily living impaired
Anxiety
Apathy
Arthralgia (joint pain)

50-59:

Skin lesion
Difficulty in walking
Haematemesis (vomiting of blood)
Insomnia (sleeplessness)
Peripheral ischaemia (impaired circulation to an extremity)
Pharyngolaryngeal pain
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Chillblains (small, itchy swellings on the skin that occur as a reaction to cold)
Feeling cold
Hyperkalaemia (damage to or disease of the kidney)

60+:

Chronic kidney disease
Renal injury (kidney injury)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Kidney infection
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 22.22%
High Blood Cholesterol: 8 people, 14.81%
Gastric Ulcer (stomach ulcer): 8 people, 14.81%
Gout (uric acid crystals building up in the body): 7 people, 12.96%
Renal Disorder (kidney disease): 6 people, 11.11%
Anaemia (lack of blood): 6 people, 11.11%
Renal Impairment (severely reduced kidney function): 5 people, 9.26%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 9.26%
Back Pain: 5 people, 9.26%
Ovarian Cancer (cancer of ovary): 4 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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