Aldactone and Buscopan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Buscopan (hyoscine butylbromide). Common drug interactions include upper limb fracture among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Buscopan. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Buscopan?

Buscopan has active ingredients of hyoscine butylbromide. eHealthMe is studying from 4,828 Buscopan users. Check the latest studies of Buscopan.

On Jul, 26, 2026

41 people who take Aldactone and Buscopan together, and have interactions are studied.

Aldactone and Buscopan drug interactions.

What are the common drug interactions of Aldactone and Buscopan, by gender? *:

female:

Upper limb fracture
Weight decreased
Acute lymphocytic leukaemia (cancer of the white blood cells)
Anaemia of malignant disease
Ascites (accumulation of fluid in the abdominal cavity)
Blood cholesterol increased
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

male:

Dehydration (dryness resulting from the removal of water)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Abdominal distension
Alopecia (absence of hair from areas of the body)
Back pain
Blood bilirubin increased
Carnitine deficiency
Cirrhosis alcoholic (chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue caused by alcoholism)
Constipation
Cough

What are the common drug interactions of Aldactone and Buscopan, by age (0-1 to 60+)? *:

0-1:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Conjunctival disorder (conjunctival disease)
Oral mucosal blistering (mouth ulcer)
Pyrexia (fever)
Rash macular (small, flat red spots)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

2-9:

n/a

10-19:

n/a

20-29:

Cardiac failure
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Haemoglobin decreased
Hepatic failure (liver failure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)

30-39:

n/a

40-49:

Acute lymphocytic leukaemia (cancer of the white blood cells)
Anaemia (lack of blood)
Anaemia of malignant disease
Cardiac failure
Fluid retention (an abnormal accumulation of fluid in the blood)
Oedema (fluid collection in tissue)
Diarrhoea
Enteritis (inflammation of the small intestine)
Weight decreased

50-59:

Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Dehydration (dryness resulting from the removal of water)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Colitis (inflammation of colon)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Quadriplegia (a four limb paralysis)
Abdominal pain
Abdominal pain upper
Cardiac arrest

60+:

Death
Cough
Cystitis bacterial (inflammation of the wall of the bladder by bacteria escherichia coli)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Iron deficiency
Muscle spasms (muscle contraction)
Nephrogenic anaemia (anaemia due to kidney disease)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain in extremity

What are the existing conditions these people have? *

High Blood Pressure: 9 people, 21.95%
Abdominal Pain: 7 people, 17.07%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 6 people, 14.63%
Cardiac Failure Chronic: 5 people, 12.20%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 4 people, 9.76%
Burning Sensation: 4 people, 9.76%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 9.76%
Diarrhea: 4 people, 9.76%
Type 2 Diabetes: 4 people, 9.76%
Varicose Vein (veins that have become enlarged and tortuous): 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactone and Buscopan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously