Defitelio and Fluconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Defitelio (defibrotide sodium) and Fluconazole (fluconazole). Common drug interactions include cerebral haemorrhage among females and acute graft versus host disease among males.

The phase IV clinical study analyzes what interactions people have when they take Defitelio and Fluconazole. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Defitelio?

Defitelio has active ingredients of defibrotide sodium. eHealthMe is studying from 4,343 Defitelio users. Check the latest studies of Defitelio.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

On Jul, 26, 2026

49 people who take Defitelio and Fluconazole together, and have interactions are studied.

Defitelio and Fluconazole drug interactions.

What are the common drug interactions of Defitelio and Fluconazole, by gender? *:

female:

Cerebral haemorrhage (bleeding within the brain)
Drug resistance (reduction in effectiveness of a drug)
Febrile neutropenia (fever with reduced white blood cells)
Hypersensitivity
Myalgia (muscle pain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Venoocclusive liver disease (small veins in the liver are obstructed)
Drug ineffective

male:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Gingival bleeding (bleeding gums)
Cardiac arrest
Diarrhoea
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Lactic acidosis (low ph in body tissues)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Haematochezia (passage of stools containing blood)
Abdominal pain

What are the common drug interactions of Defitelio and Fluconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cardiac arrest
Diarrhoea
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting

10-19:

Cerebral haemorrhage (bleeding within the brain)
Drug resistance (reduction in effectiveness of a drug)
Febrile neutropenia (fever with reduced white blood cells)
Hypersensitivity
Myalgia (muscle pain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Venoocclusive liver disease (small veins in the liver are obstructed)
Drug ineffective
Haemorrhage (bleeding)

20-29:

Acute lymphocytic leukaemia (cancer of the white blood cells)
Epistaxis (bleed from the nose)
Lactic acidosis (low ph in body tissues)

30-39:

n/a

40-49:

n/a

50-59:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Gingival bleeding (bleeding gums)
Haematochezia (passage of stools containing blood)
Abdominal pain
Blood bilirubin increased
Platelet count decreased
Blood pressure increased

60+:

n/a

What are the existing conditions these people have? *

Venoocclusive Disease (small veins in the liver are obstructed): 31 people, 63.27%
Immunodeficiency Disorders: 8 people, 16.33%
Bone Marrow Conditioning Regimen: 8 people, 16.33%
Venoocclusive Liver Disease (small veins in the liver are obstructed): 7 people, 14.29%
Febrile Bone Marrow Aplasia (bone marrow greatly decreases or stops production of blood cells): 7 people, 14.29%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 12.24%
Sedation: 4 people, 8.16%
High Blood Pressure: 4 people, 8.16%
Alloimmunisation (alloimmunity is an immune response to foreign antigens (alloantigens) from members of the same species): 4 people, 8.16%
Urination - Excessive Volume: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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