Clarithromycin and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clarithromycin (clarithromycin) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include hypersomnia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Clarithromycin and Roxicet. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Clarithromycin?

Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,044 Clarithromycin users. Check the latest studies of Clarithromycin.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

On Jul, 26, 2026

38 people who take Clarithromycin and Roxicet together, and have interactions are studied.

Clarithromycin and Roxicet drug interactions.

What are the common drug interactions of Clarithromycin and Roxicet, by gender? *:

female:

Hypersomnia (excessive daytime sleepiness (eds))
Intestinal polyp (small growths in the bowel with the potential for further growth)
Malaise (a feeling of general discomfort or uneasiness)
Back pain
Fall
Arthralgia (joint pain)
Chronic kidney disease
Nasopharyngitis (inflammation of the nasopharynx)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

male:

Chronic kidney disease
Acute respiratory distress syndrome
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Gait disturbance

What are the common drug interactions of Clarithromycin and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease

40-49:

Acute respiratory distress syndrome
Adverse drug reaction
Cerebral haemorrhage (bleeding within the brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Loss of consciousness
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Depressed mood
Emotional distress
Hepatic cyst
Injury
Metastases to bone (cancer spreads to bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Scar

60+:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Dizziness
Diarrhoea
Hypersomnia (excessive daytime sleepiness (eds))
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 44.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 36.84%
Urinary Tract Infection: 13 people, 34.21%
Stress And Anxiety: 12 people, 31.58%
Infection: 11 people, 28.95%
Fluid Retention (an abnormal accumulation of fluid in the blood): 11 people, 28.95%
High Blood Cholesterol: 11 people, 28.95%
Inflammation: 8 people, 21.05%
Swelling: 8 people, 21.05%
Depression: 8 people, 21.05%

* Approximation only. Some reports may have incomplete information.

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