Roxicet and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxicet (acetaminophen; oxycodone hydrochloride) and Hydrocortisone (hydrocortisone). Common drug interactions include cardiac disorder among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Roxicet and Hydrocortisone. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Jul, 26, 2026

39 people who take Roxicet and Hydrocortisone together, and have interactions are studied.

Roxicet and Hydrocortisone drug interactions.

What are the common drug interactions of Roxicet and Hydrocortisone, by gender? *:

female:

Cardiac disorder
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cardiovascular disorder (heart diseases)
Cellulitis (infection under the skin)
Coagulopathy (blood's ability to clot is impaired)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deafness
Decreased appetite
Dilatation ventricular

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Pleural effusion (water on the lungs)
Disseminated tuberculosis
Hepatic failure (liver failure)
Lymphohistiocytosis (an aggressive, life-threatening syndrome of excessive immune activation)
Myalgia (muscle pain)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Respiratory failure (inadequate gas exchange by the respiratory system)
Stenotrophomonas infection

What are the common drug interactions of Roxicet and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deformity (disfigurement)
Device related infection
Erythema (redness of the skin)
Muscle tightness
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain in extremity
Polyarthritis (arthritis which involves 5 or more joints simultaneously)

40-49:

Acidosis (build-up of carbon dioxide in the blood)
Anxiety
Arrhythmia (irregular heartbeat)
Blood triglycerides increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Diabetes mellitus inadequate control
Electrolyte imbalance
Haemorrhage (bleeding)

50-59:

Coagulopathy (blood's ability to clot is impaired)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deafness
Decreased appetite
Dilatation ventricular
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)
Ejection fraction decreased (systolic heart failure)
Enterococcus test positive
Extremity necrosis (death of body tissue of arms and legs)

60+:

Dysphagia (a condition in which swallowing is difficult or painful)
Gait disturbance
Arrhythmia (irregular heartbeat)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriovenous fistula site complication
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back disorder
Back pain

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 17 people, 43.59%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 17 people, 43.59%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 12 people, 30.77%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 17.95%
Nausea And Vomiting: 5 people, 12.82%
High Blood Pressure: 3 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.69%
Anaemia Of Malignant Disease: 3 people, 7.69%
Chest Pain: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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