Aleve and Ceftriaxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Ceftriaxone (ceftriaxone sodium). Common drug interactions include acute respiratory failure among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Ceftriaxone. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Ceftriaxone?

Ceftriaxone has active ingredients of ceftriaxone sodium. It is often used in typhoid fever. eHealthMe is studying from 40,991 Ceftriaxone users. Check the latest studies of Ceftriaxone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

45 people who take Aleve and Ceftriaxone together, and have interactions are studied.

Aleve and Ceftriaxone drug interactions.

What are the common drug interactions of Aleve and Ceftriaxone, by gender? *:

female:

Acute respiratory failure
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Cystitis (inflammation of the wall of the bladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug hypersensitivity
Injury

male:

Chronic kidney disease
Sepsis (a severe blood infection that can lead to organ failure and death)
Cataract (clouding of the lens inside the eye)
Dehydration (dryness resulting from the removal of water)
Fall
Gallbladder perforation (hole in gallbladder)
Osteoporosis (bones weak and more likely to break)
Pneumonia
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)

What are the common drug interactions of Aleve and Ceftriaxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dehydration (dryness resulting from the removal of water)
Nausea (feeling of having an urge to vomit)
Oral infection
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Swelling
Tooth abscess (pus formation in tooth)
Tooth infection
Vomiting

20-29:

Dermatitis allergic (inflammation of the skin due allergic reaction)
Dyspareunia (painful sexual intercourse)
Injury
Pelvic inflammatory disease
Pelvic pain
Pneumonia

30-39:

Abdominal pain
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Kidney fibrosis (excess fibrous connective tissue in kidney)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal tubular atrophy (wasting of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cystitis (inflammation of the wall of the bladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Kidney infection

50-59:

Chronic kidney disease
Sepsis (a severe blood infection that can lead to organ failure and death)
Acute respiratory failure
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Bone density decreased

60+:

Visual impairment
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Anaemia (lack of blood)
Arthralgia (joint pain)
Cholecystitis (infection of gallbladder)
Hypophysitis (inflammation of the pituitary gland)
Hypoxia (low oxygen in tissues)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Respiratory distress (difficulty in breathing)

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 28.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 22.22%
Diabetes: 8 people, 17.78%
Insomnia (sleeplessness): 8 people, 17.78%
Stress And Anxiety: 7 people, 15.56%
Nausea (feeling of having an urge to vomit): 7 people, 15.56%
Infection: 5 people, 11.11%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 11.11%
High Blood Cholesterol: 4 people, 8.89%
Headache (pain in head): 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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