Aleve and Salonpas drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Salonpas (menthol; methyl salicylate). Common drug interactions include drug ineffective among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Salonpas. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Salonpas?

Salonpas has active ingredients of menthol; methyl salicylate. eHealthMe is studying from 630 Salonpas users. Check the latest studies of Salonpas.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

17 people who take Aleve and Salonpas together, and have interactions are studied.

What are the common drug interactions of Aleve and Salonpas, by gender? *:

female:

Drug ineffective
Flatulence (flatus expelled through the anus)
Bone pain
Constipation
Fatigue (feeling of tiredness)
Peripheral swelling
Rhinorrhoea (watery mucus discharge from the nose)
Arthralgia (joint pain)
Back pain
Cardiac discomfort

male:

Asthenia (weakness)
Drug ineffective
Dry mouth
Fluid retention (an abnormal accumulation of fluid in the blood)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site infection
Infusion site pain
Infusion site pruritus (severe itching at infusion site)
Nausea (feeling of having an urge to vomit)
Pain in extremity

What are the common drug interactions of Aleve and Salonpas, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug ineffective

50-59:

Drug ineffective

60+:

Flatulence (flatus expelled through the anus)
Constipation
Feeling hot
Flushing (the warm, red condition of human skin)
Hypertension (high blood pressure)
Joint swelling
Myalgia (muscle pain)
Non-cardiac chest pain
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 17.65%
Depression: 3 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.76%
Parkinson's Disease: 2 people, 11.76%
Cardiac Failure Congestive: 2 people, 11.76%
Constipation: 2 people, 11.76%
Multiple Myeloma (cancer of the plasma cells): 2 people, 11.76%
Burning Sensation: 1 person, 5.88%
Dyspnea (difficult or laboured breathing): 1 person, 5.88%
Lung Disorder (lung disease): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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