Alimta and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alimta (pemetrexed disodium) and Diphen (diphenhydramine hydrochloride). Common drug interactions include compression fracture among females and proctalgia among males.

The phase IV clinical study analyzes what interactions people have when they take Alimta and Diphen. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Alimta?

Alimta has active ingredients of pemetrexed disodium. eHealthMe is studying from 7,702 Alimta users. Check the latest studies of Alimta.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Aug, 11, 2026

12 people who take Alimta and Diphen together, and have interactions are studied.

What are the common drug interactions of Alimta and Diphen, by gender? *:

female:

Compression fracture (fracture due to pressure caused by injury)
Dehydration (dryness resulting from the removal of water)
Epistaxis (bleed from the nose)
Fall
Hypotension (abnormally low blood pressure)
Abdominal pain upper
Blood magnesium decreased
Blood potassium decreased
Hepatitis toxic
Myalgia (muscle pain)

male:

Proctalgia (pain in the rectum)
Scrotal gangrene (death of scrotum cells)
Gastrointestinal necrosis (destruction of gastrointestinal organ)
Haematemesis (vomiting of blood)
Joint range of motion decreased (disease of joint movement)
Local swelling (swelling at the site of some application of substance or injury)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Alimta and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hepatitis toxic
Myalgia (muscle pain)
Rash

60+:

Proctalgia (pain in the rectum)
Compression fracture (fracture due to pressure caused by injury)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Back pain
Death
Dizziness
Dyspnoea (difficult or laboured respiration)
Gastrointestinal necrosis (destruction of gastrointestinal organ)
Haematemesis (vomiting of blood)
Joint range of motion decreased (disease of joint movement)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 5 people, 41.67%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 16.67%
Lung Cancer Metastatic (lung cancer spreads to other parts): 2 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%
Pain: 1 person, 8.33%
Nausea And Vomiting: 1 person, 8.33%
Nausea (feeling of having an urge to vomit): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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