Alimta and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alimta (pemetrexed disodium) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include international normalised ratio increased among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Alimta and Roxicet. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Alimta?

Alimta has active ingredients of pemetrexed disodium. eHealthMe is studying from 7,702 Alimta users. Check the latest studies of Alimta.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.



On Aug, 03, 2026

13 people who take Alimta and Roxicet together, and have interactions are studied.

Alimta and Roxicet drug interactions.

What are the common drug interactions of Alimta and Roxicet, by gender? *:

female:

  1. International normalised ratio increased
  2. Mucosal inflammation (infection of mucous membrane)
  3. Rash
  4. Drug toxicity
  5. Platelet disorder

male:

  1. Anaemia (lack of blood)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  4. Constipation
  5. Deformity (disfigurement)
  6. Emotional distress
  7. Erectile dysfunction
  8. Exostosis (formation of new bone on the surface of a bone)
  9. Glossitis (infection of tongue with soreness)
  10. Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Alimta and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Anaemia (lack of blood)
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  4. Constipation
  5. Deformity (disfigurement)
  6. Emotional distress
  7. Erectile dysfunction
  8. Exostosis (formation of new bone on the surface of a bone)
  9. Glossitis (infection of tongue with soreness)
  10. Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

  1. Neoplasm Malignant (cancer tumour): 9 people, 69.23%
  2. Lung Cancer Metastatic (lung cancer spreads to other parts): 7 people, 53.85%
  3. Oral Cancer (mouth cancer): 3 people, 23.08%
  4. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Alimta and Roxicet?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Alimta and Roxicet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Alimta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Roxicet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Alimta and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Roxicet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on pemetrexed disodium and acetaminophen; oxycodone hydrochloride (the active ingredients of Alimta and Roxicet, respectively), and Alimta and Roxicet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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