Allegra and Desloratadine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Allegra (fexofenadine hydrochloride) and Desloratadine (desloratadine). Common drug interactions include infusion site haemorrhage among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Allegra and Desloratadine. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Allegra?

Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. eHealthMe is studying from 75,498 Allegra users. Check the latest studies of Allegra.

What is Desloratadine?

Desloratadine has active ingredients of desloratadine. It is often used in allergies. eHealthMe is studying from 4,207 Desloratadine users. Check the latest studies of Desloratadine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

31 people who take Allegra and Desloratadine together, and have interactions are studied.

Allegra and Desloratadine drug interactions.

What are the common drug interactions of Allegra and Desloratadine, by gender? *:

female:

Infusion site haemorrhage (bleeding from infusion site)
Infusion site hypersensitivity
Infusion site pruritus (severe itching at infusion site)
Infusion site reaction
Infusion site swelling
Laryngitis (inflammation of the larynx)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Sinus headache (headache caused by sinus infections)

male:

Blood cholesterol increased
Blood triglycerides increased
Oedema peripheral (superficial swelling)
Pain in extremity
Pulmonary mass
Pulmonary oedema (fluid accumulation in the lungs)
Sinus disorder (disease of sinus)
Abdominal pain
Blood creatinine increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the common drug interactions of Allegra and Desloratadine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bilirubin conjugated increased
Blood bilirubin increased
Blood bilirubin unconjugated increased
C-reactive protein increased
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Liver injury

20-29:

Affective disorder (mental disorder)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Body temperature increased
Drug hypersensitivity
Drug ineffective
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Mood swings (an extreme or rapid change in mood)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Angioedema (rapid swelling of the dermis)

30-39:

Blood cholesterol increased
Blood triglycerides increased
Diabetes mellitus non-insulin-dependent
Erectile dysfunction
Headache (pain in head)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Weight increased
Back pain
Cellulitis (infection under the skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

40-49:

Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicide attempt
Weight increased
Fall

50-59:

Infusion site pain
Multiple allergies (allergy to multiple agents)
Asthma
Headache (pain in head)
Pulmonary mass
Pulmonary oedema (fluid accumulation in the lungs)
Abdominal discomfort
Abdominal pain upper
Abdominal tenderness
Blood creatinine increased

60+:

Heart rate increased
Asthenia (weakness)
Blood pressure increased
Cerebral disorder (brain disease)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Nervousness
Psychomotor hyperactivity (feelings of extreme restlessness)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 7 people, 22.58%
Seasonal Allergy (allergic condition due to certain season): 4 people, 12.90%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.90%
Immunodeficiency Common Variable: 4 people, 12.90%
Asthma: 4 people, 12.90%
Migraine (headache): 3 people, 9.68%
Stress And Anxiety: 2 people, 6.45%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 6.45%
Primary Immunodeficiency Syndrome: 2 people, 6.45%
Hypersensitivity: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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