Aloe vera and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aloe vera (aloe) and Methotrexate (methotrexate sodium). Common drug interactions include infusion site pruritus among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Aloe vera and Methotrexate. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Aloe vera?

Aloe vera has active ingredients of aloe. eHealthMe is studying from 1,457 Aloe vera users. Check the latest studies of Aloe vera.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 12, 2026

66 people who take Aloe vera and Methotrexate together, and have interactions are studied.

Aloe vera and Methotrexate drug interactions.

What are the common drug interactions of Aloe Vera and Methotrexate, by gender? *:

female:

Infusion site pruritus (severe itching at infusion site)
Infusion site reaction
Joint swelling
Fatigue (feeling of tiredness)
Headache (pain in head)
Dizziness
Nausea (feeling of having an urge to vomit)
Drug ineffective
Arthralgia (joint pain)
Erythema (redness of the skin)

male:

Nausea (feeling of having an urge to vomit)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Death
Dyspnoea (difficult or laboured respiration)
Hypersensitivity
Neoplasm malignant (cancer tumour)
Erythema (redness of the skin)
Psoriasis (immune-mediated disease that affects the skin)

What are the common drug interactions of Aloe Vera and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Erythema (redness of the skin)
Nausea (feeling of having an urge to vomit)
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Skin exfoliation (removal of the oldest dead skin cells)
Skin lesion
Vomiting
Arthralgia (joint pain)
Fatigue (feeling of tiredness)

40-49:

Drug ineffective
Drug intolerance (drug sensitivity)
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Weight decreased
Abdominal pain lower
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Dyspepsia (indigestion)
Hypoaesthesia (reduced sense of touch or sensation)

50-59:

Dysphagia (a condition in which swallowing is difficult or painful)
Erythema (redness of the skin)
Muscle tightness
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Skin discolouration (change of skin colour)
Skin infection
Abdominal pain upper
Drug hypersensitivity
Rash

60+:

Dizziness
Fatigue (feeling of tiredness)
Sinusitis (inflammation of sinus)
Stress
Systolic hypertension (an elevated systolic blood pressure)
Throat irritation
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Erythema (redness of the skin)
Infusion site mass

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 13 people, 19.70%
Immunodeficiency: 10 people, 15.15%
Psoriasis (immune-mediated disease that affects the skin): 8 people, 12.12%
Pemphigoid (tense blisters on the skin): 6 people, 9.09%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 9.09%
Iridocyclitis (inflammation of the iris and ciliary body of the eye): 6 people, 9.09%
Pain: 5 people, 7.58%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 7.58%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 7.58%
High Blood Pressure: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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