Ambien and Esgic-plus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien (zolpidem tartrate) and Esgic-plus (acetaminophen; butalbital; caffeine). Common drug interactions include depression among females and dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien and Esgic-plus. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Esgic-plus?

Esgic-plus has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 269 Esgic-plus users. Check the latest studies of Esgic-plus.

On Jul, 14, 2026

28 people who take Ambien and Esgic-plus together, and have interactions are studied.

Ambien and Esgic-plus drug interactions.

What are the common drug interactions of Ambien and Esgic-Plus, by gender? *:

female:

Depression
Oedema lower limb (fluid collection in tissue of lower leg)
Palpitations (feelings or sensations that your heart is pounding or racing)
Fatigue (feeling of tiredness)
Skin burning sensation
Anxiety disorder
Bipolar disorder (mood disorder)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Blood sodium increased
Contusion (a type of hematoma of tissue in which capillaries)

male:

Dependence
Dependent personality disorder
Loss of consciousness
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Personality disorder

What are the common drug interactions of Ambien and Esgic-Plus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiac murmur (an heart sound in valve abnormality)
Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Oedema lower limb (fluid collection in tissue of lower leg)
Blood sodium increased
Oedema (fluid collection in tissue)

40-49:

Abdominal pain
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Dehydration (dryness resulting from the removal of water)
Depression
Dizziness
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Fall
Depression
Drug ineffective
Eating disorder
Foot fracture
Gun shot wound
Head injury
Hospitalisation
Hypersensitivity

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 17.86%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 17.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 17.86%
Sleep Disorder: 4 people, 14.29%
Headache (pain in head): 4 people, 14.29%
Depression: 3 people, 10.71%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 7.14%
Oral Herpes (viral infection of mouth): 2 people, 7.14%
Hypersensitivity: 2 people, 7.14%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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