Ambien and Palladone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien (zolpidem tartrate) and Palladone (hydromorphone hydrochloride). Common drug interactions include drug dependence among females and diabetic ketoacidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien and Palladone. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Palladone?

Palladone has active ingredients of hydromorphone hydrochloride. eHealthMe is studying from 2,546 Palladone users. Check the latest studies of Palladone.

On Jul, 11, 2026

11 people who take Ambien and Palladone together, and have interactions are studied.

What are the common drug interactions of Ambien and Palladone, by gender? *:

female:

Drug dependence
Pain
Adverse event
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Bronchial hyperreactivity
Cardiac disorder
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Confusional state

male:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Overdose
Coma (state of unconsciousness lasting more than six hours)
Loss of consciousness
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Anxiety
Dependence
Depressed level of consciousness
Drug dependence
Impaired work ability

What are the common drug interactions of Ambien and Palladone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Loss of consciousness
Overdose
Depressed level of consciousness

40-49:

Dependence
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

50-59:

Adverse event
Arrhythmia (irregular heartbeat)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Haematotoxicity (toxins that destroy red blood cells)
Malignant neoplasm progression (cancer tumour came back)
Pain
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

n/a

What are the existing conditions these people have? *

Pain: 6 people, 54.55%
Pancreatic Carcinoma (pancreatic cancer): 2 people, 18.18%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 9.09%
Stress And Anxiety: 1 person, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Anaemia (lack of blood): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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