Crysvita and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Crysvita (burosumab-twza), especially for people who are also take Pravastatin Sodium, and have Phosphorus metabolism disorder.

The study is created by eHealthMe based on reports of 6,746 people who have side effects when taking Crysvita from the FDA, and is updated regularly.

What is Crysvita?

Crysvita has active ingredients of burosumab-twza. eHealthMe is studying from 6,746 Crysvita users. Check the latest studies of Crysvita.

On Jul, 11, 2026

6,746 people reported to have side effects when taking Crysvita.
Among them, 19 people (0.28%) died.

Among these 19 people:

What are other drugs people take besides Crysvita? *

What are other side effects people have before they died? *

Respiration Abnormal (abnormal breathing process): 2 people, 10.53%
Paraplegia (paralysis of the legs and lower body): 2 people, 10.53%
Disease Progression: 2 people, 10.53%
Weight Decreased: 1 person, 5.26%
Urinary Tract Infection: 1 person, 5.26%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.26%
Renal Impairment (severely reduced kidney function): 1 person, 5.26%
Pneumonia: 1 person, 5.26%
Hospitalisation: 1 person, 5.26%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.26%

What are the existing conditions these people have? *

Phosphorus Metabolism Disorder: 2 people, 10.53%
Pain: 1 person, 5.26%
Osteomalacia (softening of the bones due to a lack of vitamin d): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Crysvita:

Crysvita (6,746 reports)

Expand to all the drugs that have ingredients of burosumab-twza:

Death and drugs with ingredients of burosumab-twza

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Crysvita:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,134 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on burosumab-twza (the active ingredients of Crysvita) and Crysvita (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.