Metformin hydrochloride and Hip joint replacement - a phase IV clinical study of FDA data

Summary:

Hip joint replacement is reported as a side effect among people who take Metformin hydrochloride (metformin hydrochloride), especially for people who are female, 60+ old, also take Folic Acid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Hip joint replacement when taking Metformin hydrochloride. It is created by eHealthMe based on reports of 54,785 people who have side effects when taking Metformin hydrochloride from the FDA, and is updated regularly.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 58,646 Metformin hydrochloride users. Check the latest studies of Metformin hydrochloride.

What is Hip joint replacement?

Hip joint replacement is found to be associated with 861 drugs and 1,062 conditions by eHealthMe. Check the latest studies of Hip joint replacement.

On Jul, 11, 2026

54,785 people reported to have side effects when taking Metformin hydrochloride.
Among them, 32 people (0.06%) have Hip joint replacement.

Could Metformin hydrochloride cause Hip joint replacement?

Among these 32 people:

What is the gender of people who have Hip joint replacement when taking Metformin hydrochloride? *

female: 68.97 %
male: 31.03 %

What is the age of people who have Hip joint replacement when taking Metformin hydrochloride? *

What are other drugs people take besides Metformin hydrochloride? *

What are other side effects people have besides Hip joint replacement? *

Weakness: 8 people, 25.00%
Fatigue (feeling of tiredness): 8 people, 25.00%
Dyspnea (difficult or laboured breathing): 7 people, 21.88%
Back Pain: 7 people, 21.88%
Constipation: 6 people, 18.75%
Muscle Aches (muscle pain): 6 people, 18.75%
Nausea And Vomiting: 6 people, 18.75%
Pain: 5 people, 15.62%
Pain In Extremity: 5 people, 15.62%
Blood Glucose Increased: 5 people, 15.62%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.50%
High Blood Pressure: 3 people, 9.38%
Osteoporosis (bones weak and more likely to break): 3 people, 9.38%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.38%
High Blood Cholesterol: 2 people, 6.25%
Pain: 2 people, 6.25%
Stress And Anxiety: 1 person, 3.12%
Drowsiness: 1 person, 3.12%
Gastric Disorder (disease of stomach): 1 person, 3.12%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin hydrochloride and have Hip joint replacement?

- Check whether Hip joint replacement is associated with a drug or a condition
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- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin hydrochloride:

Metformin hydrochloride (58,646 reports)

Browse all side effects of Metformin hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hip joint replacement:

Hip joint replacement (861 drugs)

Browse all the conditions that are associated with Hip joint replacement:

Hip joint replacement (1,062 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin hydrochloride) and Metformin hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.