Amerge and Restoril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amerge (naratriptan hydrochloride) and Restoril (temazepam). Common drug interactions include feeling hot among females and road traffic accident among males.

The phase IV clinical study analyzes what interactions people have when they take Amerge and Restoril. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Amerge?

Amerge has active ingredients of naratriptan hydrochloride. It is often used in migraine. eHealthMe is studying from 1,470 Amerge users. Check the latest studies of Amerge.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.



On Jul, 16, 2026

11 people who take Amerge and Restoril together, and have interactions are studied.

Amerge and Restoril drug interactions.

What are the common drug interactions of Amerge and Restoril, by gender? *:

female:

  1. Feeling hot
  2. Headache (pain in head)
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. Injection site pain
  5. Nausea (feeling of having an urge to vomit)
  6. Pain
  7. Soft tissue injury
  8. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  9. Tremor (trembling or shaking movements in one or more parts of your body)
  10. White blood cell count increased

male:

  1. Road traffic accident
  2. Activities of daily living impaired

What are the common drug interactions of Amerge and Restoril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Grand mal convulsion (a type of generalized seizure that affects the entire brain)
  2. Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
  3. Headache (pain in head)
  4. Nausea (feeling of having an urge to vomit)
  5. Soft tissue injury

30-39:

  1. Injection site pain

40-49:

n/a

50-59:

  1. Road traffic accident
  2. Pain
  3. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  4. Tremor (trembling or shaking movements in one or more parts of your body)
  5. White blood cell count increased
  6. Activities of daily living impaired
  7. Back pain
  8. Body temperature increased
  9. Chest pain
  10. Dysgeusia (disorder of the sense of taste)

60+:

  1. Drug ineffective

What are the existing conditions these people have? *

  1. Pain: 6 people, 54.55%
  2. Sleep Disorder: 5 people, 45.45%
  3. Wheezing (a high-pitched whistling sound made while you breath): 4 people, 36.36%
  4. Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 36.36%
  5. Post-Traumatic Headache: 4 people, 36.36%
  6. Headache (pain in head): 4 people, 36.36%
  7. Head Injury: 4 people, 36.36%
  8. Neck Pain: 3 people, 27.27%
  9. Migraine Without Aura (headache without neurological problems): 3 people, 27.27%
  10. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Amerge and Restoril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Amerge and Restoril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amerge:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Restoril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Amerge and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Restoril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on naratriptan hydrochloride and temazepam (the active ingredients of Amerge and Restoril, respectively), and Amerge and Restoril (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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